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Using a double-blind, randomized controlled design to investigate the additional therapeutic effects of 3 times of combined triamcinolone and hyaluronic acid injections to 3 times of hyaluronic acid injections to patients with knee osteoarthritis.
A total of 56 patients will be enrolled and randomized into two groups, including 3 times of triamcinolone combined hyaluronic acid injections group and 3 times of hyaluronic acid injections group.
The triamcinolone combined hyaluronic acid injections group will receive 3 times of triamcinolone combined hyaluronic acid injection per week in three weeks; the hyaluronic acid group will receive hyaluronic acid injection in three weeks.
Physical activities and functional performance will be evaluated at before injection, at after one week, one month, three months, and six months of completion of 3 times of injections.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| triamcinolone and hyaluronic acid group | Experimental | combined triamcinolone (Triamcinolone 10 mg 1cc) and hyaluronic acid (2 cc) injections: one injection per week, for 3 weeks, to compare the additional therapeutic effects of combined triamcinolone and hyaluronic acid injections to hyaluronic acid injections |
|
| hyaluronic acid group | Active Comparator | hyaluronic acid (2cc) injection: one injection per week, for 3 weeks, to compare the additional therapeutic effects of combined triamcinolone and hyaluronic acid injections to hyaluronic acid injections |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Triamcinolone | Drug | compare the additional therapeutic effects of triamcinolone combined with hyaluronic acid injections to hyaluronic acid injections only to patients with knee osteoarthritis |
| Measure | Description | Time Frame |
|---|---|---|
| Functional performance assessed with the Western Ontario and McMaster Universities Osteoarthritis Index | Western Ontario and McMaster Universities Osteoarthritis Index | changes from baseline to at after one week, one month, three months, and six months of completion of injections |
| Measure | Description | Time Frame |
|---|---|---|
| 10 meter walk test | 10 meter walk as fast as possible | changes from baseline to at after one week, one month, three months, and six months of completion of injections |
| Quality of life assessed with the Knee Injury and Osteoarthritis Outcome Score |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ru-Lan Hsieh, MD | Contact | 886-2-28332211 | 2538;2531 | M001052@ms.skh.org.tw |
| Ru-Lan Hsieh, MD | Contact | 886-2-28332211 | 2538;2531 | rulan@tmu.edu.tw |
| Name | Affiliation | Role |
|---|---|---|
| Ru-Lan Hsieh, MD | Shin Kong Wu Ho-Su Memorial Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shin Kong Wu Ho-Su Memorial Hospital | Taipei | 111-01 | Taiwan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34958762 | Derived | Wang CP, Lee WC, Hsieh RL. Effects of Repeated Co-Injections of Corticosteroids and Hyaluronic Acid on Knee Osteoarthritis: A Prospective, Double-Blind Randomized Controlled Trial. Am J Med. 2022 May;135(5):641-649. doi: 10.1016/j.amjmed.2021.11.016. Epub 2021 Dec 24. |
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| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D020370 | Osteoarthritis, Knee |
| ID | Term |
|---|---|
| D001519 | Behavior |
| D010003 | Osteoarthritis |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 |
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| ID | Term |
|---|---|
| D014221 | Triamcinolone |
| D000305 | Adrenal Cortex Hormones |
| ID | Term |
|---|---|
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
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|
| Hyaluronic acid | Device | compare the additional therapeutic effects of triamcinolone combined with hyaluronic acid injections to hyaluronic acid injections only to patients with knee osteoarthritis |
|
Knee Injury and Osteoarthritis Outcome Score
| changes from baseline to at after one week, one month, three months, and six months of completion of injections |
| 5 times rapid chair rising test | rapid chair rising for 5 times as fast as possible | changes from baseline to at after one week, one month, three months, and six months of completion of injections |
| Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
| D011083 |
| Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |