Impact of Complete Surgery of Colorectal Deep Infiltrating Endometriosis on Fertility

Impact of Complete Surgery of Colorectal Deep Infiltrating Endometriosis on Fertility: Complete Surgery + IVF Versus IVF (ENDOFERT)

The ENDOFERT Study is an open, multicenter, randomized, parallel-group, controlled trial. This study includes patients presenting colorectal DIE and infertility. Patients will be randomized in two parallel-groups; one group underwent complete surgery of colorectal DIE prior to ART and the other group underwent ART alone (ratio 1:1)

Inclusion Criteria:

• Primary and secondary infertility
• Indication for IVF
• Persistent pain related to endometriosis with analgesic medical treatment failure
• Persistent pain including at least one of the following digestive symptoms related to endometriosis: Dyschesia / Sub-occlusive syndrome / Rectal bleeding / Painful defecation
• Colorectal deep infiltrating endometriosis : Whatever lesion size / With at least rectal serosal involvement / Confirmed by MRI and 1 different investigation: vaginal ultrasound echography or coloscopic CT scan or rectal endoscope ultrasound
• Eligible for DIE surgery

Exclusion Criteria:

• Contraindication to pregnancy or to IVF
• Viral risk
• Previous IVF cycle(s)
• Previous colorectal surgery
• Need of myomectomy during surgery
• The use of oocytes donor