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Inability to obtain final specimen routinely
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| Name | Class |
|---|---|
| Discovery Foundation | UNKNOWN |
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Pregnant African American women between 18 and 45 years of age will be enrolled at 20 weeks of gestation or less. Biological specimens (vaginal swabs, rectal swab) will be collected at enrollment, 23-24 weeks, at 28-29 weeks, and at the onset of labor. A urine sample will be obtained at entry and at the time of delivery for metabolomic analysis. Participants will also collect a dietary survey at entry, 23-24 weeks, and 28-29 weeks. The biological specimens will then be analyzed for their microbiomial profile. This will then be correlated with the timing of their delivery as well as other comorbidities such as obesity, hypertension, and diabetes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Preterm Delivery | African american women who present for prenatal care who experience spontaneous preterm birth |
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| Term delivery | African american women who present for prenatal care who experience term birth |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Survey, Sample collection | Other | Survey is collected on the dietary intake of both cohorts. Sample collection is done from patients in both cohorts at multiple time points. |
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| Measure | Description | Time Frame |
|---|---|---|
| Preterm Delivery | Onset of preterm labor with subsequent spontaneous preterm birth | 36 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Microbiome profile | Evaluation of characteristics of the vaginal microbiome in cohorts | 36 weeks |
| Metabolomic profile | Evaluation of characteristics of the metabolomic products present in cohort |
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Inclusion Criteria:
Exclusion Criteria:
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African american women between 18 and 45 years of age who are pregnant with a singleton and present for prenatal care at 20 weeks of gestation or less.
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| ID | Term |
|---|---|
| D047928 | Premature Birth |
| ID | Term |
|---|---|
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| ID | Term |
|---|---|
| D011795 | Surveys and Questionnaires |
| D013048 | Specimen Handling |
| ID | Term |
|---|---|
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
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Sample collection for bacterial microbiome identification and metabolic products
| 36 weeks |
| Medical comorbidities | Evaluation of the comorbidities present in the cohort | 36 weeks |
| Gut Microbiome profile | Evaluation of the characteristics of the gastrointestinal microbiome in cohorts | 36 weeks |
| Term delivery | Delivery at term | 36 weeks |
| D000091642 | Urogenital Diseases |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |