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This study aims to investigate the changes induced by HABIT-ILE in impairments, activity and participation of children with unilateral CP, as well as neuroplastic changes induced by the treatment. Visuospatial deficits will be investigated and the effect of prismatic adaptation will be measured.
This study aims to investigate the changes induced by HABIT-ILE at the 3 levels of the international classification of functioning and health (ICF) in children with unilateral CP, as well as neuroplastic changes induced by the treatment. Visuospatial deficits will be investigated and the effect of prismatic adaptation will be measured.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| prismatic adaptation | Experimental | Including 8 hours of therapy with prismatic adaptation wearing prismatic goggles during bimanual intensive and locomotor intensive intervention (HABIT-ILE). |
|
| sham goggles | Active Comparator | Including 8 hours of therapy wearing "sham goggles" during bimanual intensive and locomotor intensive intervention (HABIT-ILE). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| HABIT-ILE with prismatic adaptation | Behavioral | Bimanual and locomotor intensive intervention for 90h including 8 hours of prismatic adaptation |
|
| Measure | Description | Time Frame |
|---|---|---|
| changes in star cancellation | number of little stars omitted in a frame including many stars of different size | at baseline and after 90 hours/two weeks of intensive bimanual intervention |
| change in "Ogden Figure" test | number of elements omitted when reproducing a drawing | at baseline and after 90 hours/two weeks of intensive bimanual intervention |
| changes in line bissection | deviation from midline during line section | at baseline and after 90 hours/two weeks of intensive bimanual intervention |
| visuo-spatial pointing | pointing in a blind box in the direction of a visual cue, measuring the deviation from midline | at baseline and after 90 hours/two weeks of intensive bimanual intervention |
| proprioceptive pointing | pointing without any visual feedback in the direction of body midline and measuring deviation | at baseline and after 90 hours/two weeks of intensive bimanual intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Jebsen-Taylor test of hand function | Manual dexterity measured with objects of everyday life, measure=time to manipulate objects | at baseline and after 90 hours/two weeks of intensive bimanual intervention |
| functional magnetic resonance imaging (fMRI) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yannick Bleyenheuft, PhD | Institute of Neuroscience, Université catholique de Louvain | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bleyenheuft Yannick | Brussels | 1150 | Belgium |
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| ID | Term |
|---|---|
| D002547 | Cerebral Palsy |
| ID | Term |
|---|---|
| D001925 | Brain Damage, Chronic |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| HABIT-ILE without prismatic adaptation | Behavioral | Bimanual and locomotor intensive intervention for 90h including 8 hours of prismatic adaptation wearing sham goggles. |
|
cortical activation (changes in voxels activation) |
| at baseline and after 90 hours/two weeks of intensive bimanual intervention |
| Box and blocks | number of blocks manipulated in one minute | at baseline and after 90 hours/two weeks of intensive bimanual intervention |
| Assisting Hand Assessment | help provided by the paretic hand to the non-paretic one in bimanual coordination | at baseline and after 90 hours/two weeks of intensive bimanual intervention |
| "ABILHAND-Kids" questionnaire | parents-reported questionnaire measuring manual ability | at baseline and after 90 hours/two weeks of intensive bimanual intervention |
| "ACTIVLIM-CP" questionnaire | parents-reported questionnaire measuring global activity performance | at baseline and after 90 hours/two weeks of intensive bimanual intervention |
| Canadian Occupationnal Performance Measure | setting therapeutic goals with parents and measuring both performance and satisfaction (%) | at baseline and after 90 hours/two weeks of intensive bimanual intervention |
| diffusion tensor imaging (DDTI) | measuring changes in white matter tracts (fractional anisotropy, number of voxels) | at baseline and after 90 hours/two weeks of intensive bimanual intervention |