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| Name | Class |
|---|---|
| St. Olavs Hospital | OTHER |
| Liverpool John Moores University | OTHER |
| Australian Catholic University | OTHER |
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The primary aim of this trial is to investigate adipose tissue function in women with and without polycystic ovary syndrome (PCOS). PCOS is a common endocrine disorder in young women. The pathogenesis behind PCOS is complex and only partly understood, and deeper mechanistic insight is needed. Insulin resistance is a central feature of PCOS, and recent studies have suggested that this is linked to aberrant adipose tissue function. Exercise training has been found to improve the symptoms in PCOS, but we need more knowledge about why. While processes involved in skeletal muscle oxidative remodeling are well described, it is to a large extent unknown whether the oxidative capacity of human adipose tissue is modified by endurance training. The women included in this study will be matched (for body mass index, body weight, and age) to participants in another study. This will enable the investigators to do a comparison between cases (women with PCOS) and controls (women without PCOS) at baseline, and to assess the responses to exercise training in adipose tissue.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 4x4 minutes interval training | Experimental | 4x4 minutes high intensity interval training with 4 minute intervals |
|
| 10x1 minute interval training | Experimental | 10x1 minute high intensity interval training with 1 minute intervals |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 4x4 minutes high intensity interval training | Behavioral | Treadmill running/walking with 10 minutes warm-up at 60-70% of maximum heart rate, 4x4 minute intervals at 90-95% of maximum heart rate separated by 3-minutes active pauses at 60-70% of maximum heart rate, and 3 minutes cool-down. |
| Measure | Description | Time Frame |
|---|---|---|
| mitochondrial oxidative phosphorylation capacity | assessed with high resolution respirometry | 16 weeks |
| production of reactive oxygen species | assessed with high resolution respirometry | 16 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Adipokine secretion | 16 weeks | |
| lipid droplet size in adipocytes | 16 weeks | |
| Whole-body fat oxydation rate |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jorunn L Helbostad, phd prof | Norwegian University of Science and Technology | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre of Exercise and Nutrition, Mary MacKillop Institute for Health Research, AUC | Melbourne | Australia | ||||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32848854 | Result | Lionett S, Kiel IA, Camera DM, Vanky E, Parr EB, Lydersen S, Hawley JA, Moholdt T. Circulating and Adipose Tissue miRNAs in Women With Polycystic Ovary Syndrome and Responses to High-Intensity Interval Training. Front Physiol. 2020 Jul 30;11:904. doi: 10.3389/fphys.2020.00904. eCollection 2020. | |
| 35329952 | Result |
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|
|
| 10x1 minute high intensity interval training | Behavioral | Treadmill running/walking with 10 minutes warm-up at 60-70% of maximum heart rate, ten 1-minute intervals at maximal intensity (that can be performed for one minute), separated by 1-minutes active pauses at 60-70% of maximum heart rate, and 3 minutes cool-down. |
|
|
| 16 weeks |
| Insulin sensitivity | 2h oral glucose tolerance test (OGGT) | 16 weeks |
| Whole-body peak oxygen uptake | 16 weeks |
| Adipokine gene expression | 16 weeks |
| Total protein abundance in adipose tissue | quantified using standard Western Blot method | 16 weeks |
| "blood markers of cardiometabolic health" | 16 weeks |
| Body composition | assessed by impedance scale (InBody) | 16 weeks |
| blood pressure | 16 weeks |
| endothelial function | measured by flow-mediated dilatation of the brachial artery | 16 weeks |
| Intima media thickness | measured by ultrasound | 16 weeks |
| Total cholesterol in blood | 16 weeks |
| HDL cholesterol in blood | 16 weeks |
| LDL cholesterol in blood | 16 weeks |
| blood glucose | 16 weeks |
| blood insulin | 16 weeks |
| Glycosylated Hemoglobin (HbA1c) in blood | 16 weeks |
| Department of circulation and medical imaging , NTNU |
| Trondheim |
| 7491 |
| Norway |
| Kiel IA, Jones H, Lionett S, Rosbjorgen R, Lydersen S, Vanky E, Moholdt T. Cardiovascular Health Does Not Change Following High-Intensity Interval Training in Women with Polycystic Ovary Syndrome. J Clin Med. 2022 Mar 15;11(6):1626. doi: 10.3390/jcm11061626. |
| 33841184 | Result | Lionett S, Kiel IA, Rosbjorgen R, Lydersen S, Larsen S, Moholdt T. Absent Exercise-Induced Improvements in Fat Oxidation in Women With Polycystic Ovary Syndrome After High-Intensity Interval Training. Front Physiol. 2021 Mar 24;12:649794. doi: 10.3389/fphys.2021.649794. eCollection 2021. |
| ID | Term |
|---|---|
| D011085 | Polycystic Ovary Syndrome |
| ID | Term |
|---|---|
| D010048 | Ovarian Cysts |
| D003560 | Cysts |
| D009369 | Neoplasms |
| D010049 | Ovarian Diseases |
| D000291 | Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D000072696 | High-Intensity Interval Training |
| D015444 | Exercise |
| ID | Term |
|---|---|
| D064797 | Physical Conditioning, Human |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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