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| Name | Class |
|---|---|
| St. Olavs Hospital | OTHER |
| Liverpool John Moores University | OTHER |
| Australian Catholic University | OTHER |
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The aim is to investigate whether 16 weeks of high intensity interval training, followed by 36 weeks of home-based exercise, will improve menstrual frequency in women with Polycystic Ovary Syndrome (PCOS) compared with a non-exercising control group.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 4x4 minutes interval training | Experimental | 4x4 minutes high intensity interval training with 4 minute intervals |
|
| 10x1 minute interval training | Experimental | 10x1 minute high intensity interval training with 1 minute intervals |
|
| control | No Intervention | Physical activity recommended |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 4x4 minutes high intensity interval training | Behavioral | Treadmill running/walking with 10 minutes varm-up at 60-70% of maximum heart rate, 4x4 minute intervals at 90-95% of maximum heart rate separated by 3-minutes active pauses at 60-70% of maximum heart rate, and 3 minutes cool-down. |
| Measure | Description | Time Frame |
|---|---|---|
| Menstrual frequency | Electronic menstrual diary | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Body composition | Bioimpedance scale and/or DXA, waist circumference, waist/hip-ratio | 16 weeks, and 36 weeks |
| Aerobic capacity | Maximal oxygen uptake measured with Oxygon Pro, Jaeger |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Trine Moholdt, phd | Norwegian University of Science and Technology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre of Exercise and Nutrition, Mary MacKillop Institute for Health Research, AUC | Melbourne | Australia | ||||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32848854 | Result | Lionett S, Kiel IA, Camera DM, Vanky E, Parr EB, Lydersen S, Hawley JA, Moholdt T. Circulating and Adipose Tissue miRNAs in Women With Polycystic Ovary Syndrome and Responses to High-Intensity Interval Training. Front Physiol. 2020 Jul 30;11:904. doi: 10.3389/fphys.2020.00904. eCollection 2020. | |
| 35019901 | Derived |
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|
|
| 10x1 minute high intensity interval training | Behavioral | Treadmill running/walking with 10 minutes varm-up at 60-70% of maximum heart rate, ten 1-minute intervals at maximal intensity (that can be performed for one minute), separated by 1-minutes active pauses at 60-70% of maximum heart rate, and 3 minutes cool-down. |
|
|
| 16 weeks, and 36 weeks |
| Endothelial function | Flow mediated dilatation of the brachial artery | 16 weeks, and 36 weeks |
| Insulin sensitivity | 2h oral glucose tolerance test (OGGT) | 16 weeks, and 36 weeks |
| Intima-media thickness | Ultrasound of the caroid intima-media thickness | 16 weeks, and 36 weeks |
| Oxidative capacity | carbohydrate- and fat oxidation measured with Oxygon Pro, Jaeger | 16 weeks, and 36 weeks |
| Low-grade systematic inflammation | Blood samples and adipose tissue | 16 weeks, and 36 weeks |
| Adipose tissue morphology and function | Adipose tissue biopsy | 16 weeks, (and 36 weeks if funded) |
| Hormone profile, blood lipids and blood values | Blood samples | 16 weeks, and 36 weeks |
| Blood pressure | Systolic and diastolic measured with automatic blood pressure device | 16 weeks, and 36 weeks |
| Quality of life | PCOS-specific Quality of Life Questionnaire | 16 weeks |
| Quality of life | PCOS-specific Quality of Life Questionnaire | 36 weeks |
| Physical activity | Physical activity monitor armband (amount and intensity) | 16 weeks, and 36 weeks |
| Adipose tissue mRNA expression | mRNA analysis of adipose tissue | 16 weeks, (and 36 weeks if funded) |
| ovarian morphology | vaginal ultrasound | 16 weeks, and 36 weeks |
| Pregnancy rate | In total, between groups, and among those trying to become pregnant when entering the study | 16 weeks , and 36 weeks |
| Enjoyment | Physical Activity Enjoyment Scale (PACES) questionnaire | weekly up to 16 weeks |
| Diet | Diet diary | 16 weeks |
| Diet | Diet diary | 36 weeks |
| Department of circulation and medical imaging , NTNU |
| Trondheim |
| 7491 |
| Norway |
| Kiel IA, Lionett S, Parr EB, Jones H, Roset MAH, Salvesen O, Hawley JA, Vanky E, Moholdt T. High-Intensity Interval Training in Polycystic Ovary Syndrome: A Two-Center, Three-Armed Randomized Controlled Trial. Med Sci Sports Exerc. 2022 May 1;54(5):717-727. doi: 10.1249/MSS.0000000000002849. Epub 2022 Jan 12. |
| 33841184 | Derived | Lionett S, Kiel IA, Rosbjorgen R, Lydersen S, Larsen S, Moholdt T. Absent Exercise-Induced Improvements in Fat Oxidation in Women With Polycystic Ovary Syndrome After High-Intensity Interval Training. Front Physiol. 2021 Mar 24;12:649794. doi: 10.3389/fphys.2021.649794. eCollection 2021. |
| 32086359 | Derived | Kiel IA, Lionett S, Parr EB, Jones H, Roset MAH, Salvesen O, Vanky E, Moholdt T. Improving reproductive function in women with polycystic ovary syndrome with high-intensity interval training (IMPROV-IT): study protocol for a two-centre, three-armed randomised controlled trial. BMJ Open. 2020 Feb 20;10(2):e034733. doi: 10.1136/bmjopen-2019-034733. |
| ID | Term |
|---|---|
| D011085 | Polycystic Ovary Syndrome |
| ID | Term |
|---|---|
| D010048 | Ovarian Cysts |
| D003560 | Cysts |
| D009369 | Neoplasms |
| D010049 | Ovarian Diseases |
| D000291 | Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D000072696 | High-Intensity Interval Training |
| D015444 | Exercise |
| ID | Term |
|---|---|
| D064797 | Physical Conditioning, Human |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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