Position of the tip of the inner catheter and air bubbles detection (at time,5min 10min)during embryo transfer influence the pregnancy rate in ICSI cycles .

The aim of this study is to assess the relationship between the position of the tip of the inner catheter, the position of the air bubbles (at time , 5 min ,10 min )after embryo transfer and pregnancy rate outcome in ICSI cycles. Most IVF teams consider not touching the endometrium and the uterine fundus with replacement of the embryos in the lumen of the endometrial cavity the most important factors for successful embryo transfer, it is highly recommended to use agents that can facilitate a smooth embryo transfer and reduce unintended stimulation of the fundus, for example the application of soft-tipped catheters, which can improve pregnancy rate.

The advantage of using the air and liquid content for catheter loading is to prevent the embryo from adhering to the wall of the catheter at the time of injection.The presence of two air bubbles on both sides of the medium that contains the embryo prevents the transfer of the embryo within the catheter and beside, in the transfer under ultrasonographic guidance, the air bubbles are often considered a marker for the embryo's position in the uterus.

Inclusion Criteria:

• BMI < 30 kg/ m2.
• Between 20 and 35years old.
• FSH levels on cycle day 3 of <12 mIU/mL.
• Both ovaries present deprived of morphological abnormalities and adequately visualized in Transvaginal ultrasound.
• Grade one or two embryo quality.

Exclusion Criteria:

• Hydrosalpinx.
• Intrauterine lesion.
• Patients undergoing ET after cryopreservation.
• Blood present on the catheter during the transfer procedure.
• A difficult transfer or with a suspicion of touching the fundus.
• Endometrial thickness less than 8mm.
• Known allergic reaction against one of the ingredient of the medications used during the study.

prospective observational study