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Thromboembolism is an important perioperative complication in major thoracic surgery, even though current guidelines have recommended postoperative administration of heparin or LMWH for thromboprophylaxis for those high-risk patients, there are still many cases of thromboembolism. Therefore, as the guideline itself writes, the investigators believe the rational of dose and timing of heparin in thoracic surgery are still not well established. Therefore, the investigators aimed to conduct this randomized controlled study to explore the safety and efficacy of preoperative Administration of Heparin as Thromboprophylaxis in Major Thoracic Surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| case group | Experimental | start heparin sodium (5000IU, BID) upon admission, and continue until discharge |
|
| control group | Active Comparator | start heparin sodium (5000 IU,BID) from postoperative day 1, and continue until discharge |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Heparin | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| intraoperative bleeding volume (ml) | During the operation, the blood loss of each patient was collected and measured, and recorded by the investigators. | the bleeding volume (ml) during operation in the operation room for all patients |
| chest tube drainage volume (ml) | from postoperative day 1 to chest tube remove(usually on postoperative day 3 for lobectomy or thymectomy,on postoperative day 7 for esophagectomy ) | |
| thromboembolism occurence rate (%) | within 30 days after surgery | |
| APTT (s) | on postoperative day 1 for both group | |
| PT(s) | on postoperative day 1 for both group | |
| INR | on postoperative day 1 for both group | |
| blood platlet count(/L) | on postoperative day 1 for both group | |
| chest tube drainage duration (days) | from postoperative day 1 to chest tube remove(usually on postoperative day 3 for lobectomy or thymectomy,on postoperative day 7 for esophagectomy ) |
| Measure | Description | Time Frame |
|---|---|---|
| PT(s) | rightly upon hospital admission day | |
| APTT(s) | rightly upon hospital admission day | |
| INR |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yi-Dan Lin, MD | Contact | +86 18980602136 | hanyudeng@stu.scu.edu.cn | |
| Han-Yu Deng, MD | Contact | +86 18200295920 | 907151184@qq.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of thoracic surgery, west china hospital, sichuan university | Recruiting | Chengdu | Sichuan | 610041 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28523161 | Derived | Deng HY, Shi CL, Li G, Luo J, Wang ZQ, Lin YD, Liu LX, Zhou QH. The safety profile of preoperative administration of heparin for thromboprophylaxis in Chinese patients intended for thoracoscopic major thoracic surgery: a pilot randomized controlled study. J Thorac Dis. 2017 Apr;9(4):1065-1072. doi: 10.21037/jtd.2017.03.148. |
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| ID | Term |
|---|---|
| D006493 | Heparin |
| ID | Term |
|---|---|
| D006025 | Glycosaminoglycans |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
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| rightly upon hospital admission day |
| blood platlet count(/L) | rightly upon hospital admission day |