The Impact of Different Anticoagulant Therapy on Hemorrhage and Coagulation After Thoracic Surgery

The Impact of Different Anticoagulant Therapy on Hemorrhage and Coagulation After Thoracic Surgery

The purpose of this study is to determine whether the use of different dose of LMWH compared with fondaparinux for thromboprophylaxis is efficacious and safety after thoracic surgery.

Inclusion Criteria:

• clinical diagnosis of esophageal carcinoma and planned for esophagectomy
• clinical diagnosis of lung carcinoma and planned for lung resection
• general anesthesia combined with epidural anesthesia

Exclusion Criteria:

• blood clotting disfunction before surgery
• anticoagulating or antiplatelet history before surgery
• low blood platelets count
• hemorrhagic disease
• cerebral hemorrhage
• cerebral,spinal,ophthalmologic operation history
• peptic ulcer
• bleeding>400ml in operation
• bleeding>100ml/h after operation
• blood transfusion in or after operation
• severe renal or liver disfunction
• severe hypertension