This study evaluates the effect of adaptative Intensity-Modulated Radiation Therapy (IMRT) in the treatment of locally advanced cervical cancer on acute genito-urinary (GU), and gastrointestinal (GI) toxicities. Every patients will be treated according to the adaptative IMRT strategy.

Inclusion Criteria:

• Cervix carcinoma proved by histology
• According International Federation of Gynecology and Obstetrics (FIGO) classification, stages IB2, IIA, IIB, IIIA and IIIB without lumbo-aortic lymph node damage (surgical or radiologic)
• Patient treated with radio-chemotherapy then curietherapy with curative aim, validated in multidisciplinary meeting
• Renal, hepatic and cardiovascular functions that allow administration of the associated systemic treatment
• Older than 18 years
• Good general status, World Health Organization less or equal to 1
• Signed informed consent

Exclusion Criteria:

• History of cancer that is not controlled and / or treated for less than 5 years (excepted for cutaneous baso-cellular cancer)
• History of pelvic irradiation
• Simultaneous participation to another research that could interfere with the study results
• Pregnant or breastfeeding patient
• Patient under tutor or guardian
• Patient not able to respect medical follow-up for geographical, social or psychological reasons
• Not affiliated to a system of French social security

Not authorized in France