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Transcatheter Aortic Valve Implantation (TAVI) indications are progressing rapidly as an alternative to conventional surgery for aortic stenosis cure. Despite a high rate of procedural success, some patients do not benefit from the procedure. The investigators hypothesis is that aortic stiffness may be of major prognostic significance after stenosis relief.
The aim of this study is to test the prognostic impact of aortic stiffness estimated by the volume of calcifications of the thoracic aorta on the CT-scan performed systematically before the procedure. This prognostic value will be assessed in 4 independent cohorts issued from 4 french cities (Lyon, Rouen, Paris, Clermont-Ferrand).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Transcatheter Aortic Valve Implantation | Lyon and Paris cohorts : 900 patients will be used to test the prognostic value of aortic calcifications and to propose a risk score Clermont and Rouen cohorts (700 patients) will be used to test in an independent group, the predictive value of the risk score |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcatheter Aortic Valve Implantation (TAVI) | Device | TAVI is a well-accepted method for aortic valve replacement without surgery. It is currently proposed to patients at high surgical risk or contraindicated to surgery. It consists of introducing a valve inserted inside a stent by the femoral artery in most cases. Aortic calcifications will be determined by the analysis of the CT-scan performed systematically before the procedure. A semi-automated software (CreaTools) will be used |
| Measure | Description | Time Frame |
|---|---|---|
| Cardiovascular mortality | Number of death of cardiovascular cause will be analyzed | censored on 3 March 2017 |
| Measure | Description | Time Frame |
|---|---|---|
| All-cause deaths | Number of death of all causes will be analyzed | censored on 3 March 2017 |
| left ventricular remodeling | Echocardiographic measure will be done |
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Inclusion Criteria:
Exclusion Criteria:
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Patients of both sex presenting with a severe aortic stenosis with the indication of aortic replacement by TAVI
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital de la Croix Rousse | Lyon | 69004 | France |
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| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D001024 | Aortic Valve Stenosis |
| D002114 | Calcinosis |
| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D000082862 | Aortic Valve Disease |
| D006349 | Heart Valve Diseases |
| D014694 | Ventricular Outflow Obstruction |
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| ID | Term |
|---|---|
| D065467 | Transcatheter Aortic Valve Replacement |
| ID | Term |
|---|---|
| D019918 | Heart Valve Prosthesis Implantation |
| D006348 | Cardiac Surgical Procedures |
| D013504 | Cardiovascular Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
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|
| censored on 3 March 2017 |
| left ventricular ejection fraction | Echocardiographic measure will be done | censored on 3 March 2017 |
| diastolic function | Echocardiographic measure will be done | censored on 3 March 2017 |
| D002128 | Calcium Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D019919 | Prosthesis Implantation |
| D019616 | Thoracic Surgical Procedures |