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Major abdominal surgeries are associated with severe abdominal pain, which can affect respiratory and cardiac functions, if insufficiently managed. This increases the incidence of post-operative morbidity.
The objective of this study was to detect the efficacy and safety of magnesium sulphate as an adjuvant to the analgesia offered by local anesthetic in ultrasound guided TAP block in patients undergoing total abdominal hysterectomy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Magnesium group | Active Comparator | patients received ultrasound guided TAP block with 20 mL of 0.25% bupivacaine plus 2 mL magnesium sulphate 10% (200 mg), on each side of the abdominal wall. |
|
| control group | Placebo Comparator | patients received ultrasound guided TAP block with 20 mL of 0.25% bupivacaine on each side of the abdominal wall. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Magnesium Sulfate | Drug | ultrasound guided TAP block with 20 mL of 0.25% bupivacaine plus 2 mL magnesium sulfate 10% (200 mg), on each side of the abdominal wall. |
|
| Measure | Description | Time Frame |
|---|---|---|
| total postoperative morphine consumption | total amount of rescue morphine consumption in the first 24 hours postoperatively | postoperative 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| postoperative pain | postoperative pain measured by VAS score recorded in the first 24 hours postoperatively | postoperative 24 hours |
| first request of rescue analgesia | time to the first requirement of rescue analgesia during the first 24 hours postoperatively |
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Inclusion Criteria:
Exclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29149143 | Derived | Abd-Elsalam KA, Fares KM, Mohamed MA, Mohamed MF, El-Rahman AMA, Tohamy MM. Efficacy of Magnesium Sulfate Added to Local Anesthetic in a Transversus Abdominis Plane Block for Analgesia Following Total Abdominal Hysterectomy: A Randomized Trial. Pain Physician. 2017 Nov;20(7):641-647. |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D008278 | Magnesium Sulfate |
| D002045 | Bupivacaine |
| ID | Term |
|---|---|
| D017616 | Magnesium Compounds |
| D007287 | Inorganic Chemicals |
| D013431 | Sulfates |
| D013464 | Sulfuric Acids |
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| Bupivacaine | Drug | ultrasound guided TAP block with 20 mL of 0.25% bupivacaine on each side of the abdominal wall. |
|
| postoperative 24 hours |
| side effects | occurrence of side effects during the first 24 hours postoperatively | postoperative 24 hours |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013456 |
| Sulfur Acids |
| D013457 | Sulfur Compounds |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |