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| Name | Class |
|---|---|
| University of California, San Francisco | OTHER |
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In this study, the investigators are looking at how people make decisions about reward-related items, both monetary and food related after taking either the dopamine agonist bromocriptine or the COMT inhibitor tolcapone, in healthy control subjects. Subjects will fill self-report questionnaires and undergo an MRI scan.
The investigators aim to understand how the brain's dopamine system impacts monetary and food-related decision making. The investigators aim to use tolcapone and bromocriptine due to the temporary change in the levels of dopamine in the brain. The investigators also aim to determine if genetics, personality traits, or a family history of alcoholism change how these drugs affect decision making.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental: Tolcapone | Experimental | Drug: Tolcapone 200mg (single dose) administered at study visit |
|
| Comparator: Placebo | Placebo Comparator | Drug: Placebo for tolcapone administered at study visit |
|
| Experimental: Bromocriptine | Experimental | Drug: Bromocriptine 1.25mg (single dose) administered at study visit |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tolcapone | Drug | Tolcapone 200mg (single dose) administered at study visit |
|
| Measure | Description | Time Frame |
|---|---|---|
| Measure Effects of Placebo,Tolcapone, Bromocriptine on Reaction Time | Participants will play the Dictator Game. Behavioral responses to the game during each arm (placebo, tolcapone, and bromocriptine) will be measured by subject reaction time . | 3 weeks |
| Measure Effects of Placebo,Tolcapone, Bromocriptine on Accuracy | Participants will play the Dictator Game. Behavioral responses to the game during each arm (placebo, tolcapone, and bromocriptine) will be measured by subject accuracy (correct or incorrect responses). | 3 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Measure Observed Changes in Resting State Neural Activity | Resting-state data will be processed off-line using neuroimaging analysis software according to standard procedures for image slice-timing correction, realignment, normalization and smoothing. Changes in regional brain activity will be measured during the placebo, tolcapone and bromocriptine conditions. | 3 weeks |
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Inclusion Criteria:
Exclusion Criteria
MRI Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Andrew Kayser, MD,PhD | University of California, San Francisco | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of California, Berkeley | Berkeley | California | 94704 | United States | ||
| University of California, San Francisco |
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| ID | Term |
|---|---|
| D016739 | Behavior, Addictive |
| ID | Term |
|---|---|
| D003192 | Compulsive Behavior |
| D007175 | Impulsive Behavior |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D000077867 | Tolcapone |
| D001971 | Bromocriptine |
| ID | Term |
|---|---|
| D001577 | Benzophenones |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
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| Placebo | Drug | Placebo (200mg) administered at study visit |
|
| Bromocriptine | Drug | Drug: Bromocriptine 1.25 mg (single dose) administered at study visit |
|
|
| Measure Observed Changes in Task Dependent Neural Activity | Task dependent fMRI data will be processed off-line using neuroimaging analysis software according to standard procedures for image slice-timing correction, realignment, normalization and smoothing. Changes in task dependent brain activity will be measured during the placebo, tolcapone and bromocriptine conditions. | 3 weeks |
| San Francisco |
| California |
| 94158 |
| United States |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |
| D009596 | Nitrophenols |
| D010636 | Phenols |
| D007659 | Ketones |
| D009574 | Nitro Compounds |
| D004879 | Ergotamines |
| D004876 | Ergot Alkaloids |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D004873 | Ergolines |
| D006576 | Heterocyclic Compounds, 4 or More Rings |
| D000072471 | Heterocyclic Compounds, Fused-Ring |