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This study evaluate the metabolic effects of orally ingested ketone bodies. The study is conducted as a randomized, cross over study.
Subject participate for two separate days; i) intervention, ii) placebo. Intervention: subjects drink ketone body solution. Tracer kinetics on glucose and lipid metabolism is applied. Muscle tissue and adipose tissue biopsies are taken.
Placebo: subjects drink saline. Same sampling as on intervention day.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention | Active Comparator | Subjects drink 3-hydroxybuturate |
|
| Placebo | Placebo Comparator | Subjects drink saline |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 3-hydroxybuturate | Other | Drink of ketone bodies |
| |
| Placebo |
| Measure | Description | Time Frame |
|---|---|---|
| 3-hydroxybuturate | blood level of 3-hydroxybuturate | 0-270 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Glucose | Glucose tracer kinetics, endogenous glucose production, muscle biopsy | 0-270 minutes |
| lipid metabolism | Palmitate tracer kinetics, free fatty acid accumulation, adipose tissue biopsies |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aarhus University Hospital | Aarhus | 8000 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32794582 | Derived | Svart M, Rittig N, Pedersen SB, Jessen N, Moller N. Oral 3-hydroxybutyrate ingestion decreases endogenous glucose production, lipolysis, and hormone-sensitive lipase phosphorylation in adipose tissue in men: a human randomized, controlled, crossover trial. Diabet Med. 2021 Feb;38(2):e14385. doi: 10.1111/dme.14385. Epub 2020 Sep 22. |
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| Other |
Drink of saline |
|
| 0-270 minutes |