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Investigators hypothesize that Immunoglobine (Ig) production is influenced by the microbiota of the gut. Investigators will compare microbiota-dependent Ig production in the bronchoalveolar lavage fluid of patients with and without antibiotic therapy in order to detect significant differences.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with antibiotic therapy | Patients with antibiotic therapy for 2 weeks. |
| |
| Patients without antibiotic therapy | Patients without any antibiotic therapy in the last 3 months. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Anti-Bacterial Agents | Drug | administration of any antibiotic substance(s) over the course of 2 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| IgA levels in the bronchoalveolar lavage fluid | 2 weeks of ICU stay |
| Measure | Description | Time Frame |
|---|---|---|
| number of detected bacterial, viral, and fungal infections per patient | through study completion, an average of 2 months |
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Inclusion Criteria:
Exclusion Criteria:
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Consecutive inclusion of eligible patients admitted to the ICU.
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| Name | Affiliation | Role |
|---|---|---|
| Oliver Robak, MD | Medical University of Vienna | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University of Vienna | Vienna | 1090 | Austria |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 1582684 | Background | Hoogkamp-Korstanje JA, de Koning J, Heesemann J, Festen JJ, Houtman PM, van Oyen PL. Influence of antibiotics on IgA and IgG response and persistence of Yersinia enterocolitica in patients with Yersinia-associated spondylarthropathy. Infection. 1992 Mar-Apr;20(2):53-7. doi: 10.1007/BF01711062. |
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| ID | Term |
|---|---|
| D000900 | Anti-Bacterial Agents |
| ID | Term |
|---|---|
| D000890 | Anti-Infective Agents |
| D045506 | Therapeutic Uses |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
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bronchoalveolar lavage fluid of patients with and without antibiotic therapy.