Vaginal Estriol Before and Vaginal Surgery for Prolapse

Effects on Vaginal Health and Quality of Life in Postmenopausal Women Using Ultra Low Topic Estriol Before Vaginal Surgery for Pelvic Statics Disorders

The purpose of this study is to determine whether the vaginal estriol before vaginal surgery for pelvic statics disorders is more efficacy of no estriol treatment on vaginal health and quality of life.

The aim of this randomized study was to evaluate the efficacy of low concentration of vaginal estriol gel (0.005%, 50 micrograms/1 g vaginal gel) in women with pelvic statics disorders before vaginal surgical treatment (group A), assessing the vaginal dryness, dysuria, vaginal maturation index (VMI), pH and the Vaginal Health Index (VHI). Secondary, to investigate the changes of sexual function and QoL. Women without pre surgical estriol treatment constituted the control group (group B).

Inclusion Criteria:

• genital dryness,
• irritation/burning/itching of vulvas or vagina
• decreased lubrication with sexual activity
• discomfort or pain with sexual activity
• decreased arousal, orgasm, desire
• dysuria.

Exclusion Criteria:

• previous surgeries for pelvic organ prolapse
• urinary incontinence
• usage of medication
• chronic medical illness
• body mass index (BMI) ≥ 35 kg/m2
• endometrial thickness equal to or greater than 4 mm
• abnormal uterine bleeding
• hormone-dependent malignancies
• history of thromboembolic disease
• liver disease
• usage of HT for less than 3 months
• usage of phytoestrogens within 1 month before the start of the study
• partner affected by sexual disorder
• conflicting with the partner