Vaginal Estrogens Comparative Trial on Pelvic Organ Prolapse Patients

Randomized, Blinded Trial Comparing Vaginal Estrogens on Pelvic Organ Prolapse Patients

To evaluate the difference of three vaginal estrogens creams comparative with placebo on improvement of hormonal cytology, local and systemic climacteric complaints, as well as its endometrial security.

Inclusion Criteria:

• post menopause women
• normal oncotic cytology and mammogram
• any grade of pelvic organ prolapse with surgery indication and ultrasound with endometrium measure less than 5 mm

Exclusion Criteria:

• vaginal bleeding
• hormonal replacement on the past three months
• renal or hepatic desease
• porfiria
• past venous thromboembolism; ulcerated prolapse