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Malnutrition in oncologic patients has a negative impact on post- surgical recovery, survival and quality of life. The etiology of malnutrition in cancer patients is multifactorial, therefore, the nutritional assessment should be carried out by different parameters. The objective of this study is to investigate the association and prognostic value of five distinct methods of nutritional assessment (molecular, body composition, functional, anthropometric and subjective) in relation to postoperative complications and short-term survival in patients with cancer. Regarding the molecular parameter, mtor signaling pathwayon will be assessed in rectus muscle samples, harvested in the moment of the operation. Body composition was assessed by computed tomography (CT) and bioelectrical impedance test was conducted to evaluate the phase angle. Handgrip strength was used to determine functionality. The percentage of weight loss in relation to usual weight was the anthropometric parameter used. Subjective Global Assessment (SGA) was used to provide the nutritional diagnosis. Postoperative complications were classified according to the Dindo and Clavien classification. Overall time survival was the period between the first assessment of the patients until death or end of follow-up. Chi-square test, t test, Kaplan-Meier method and the Log Rank test and regression analysis will be used (p <0.05).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cancer group 1 | Colorectal cancer patients, under 18 years old, no inflammatory disease, weight loss greater 10% habitual body weight, sarcopenic. | ||
| Control group | No cancer patients, under 18 years old, no inflammatory disease, no weight loss, no sarcopenic. |
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| Measure | Description | Time Frame |
|---|---|---|
| Postoperative complications | According to the Dindo-Clavien protocol | August, 2016 |
| Measure | Description | Time Frame |
|---|---|---|
| Survival | Follow up using medical records and telephone contacts | July, 2016 |
| Measure | Description | Time Frame |
|---|---|---|
| mtor signaling pathway | mTOR Elisa kits | December, 2016 |
Inclusion Criteria:
Exclusion Criteria:
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Cancer patients that will be submitted a surgical treatment at University Hospital of University Federal of Minas Gerais.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UFMG Hospital | Belo Horizonte | Minas Gerais | 30640100 | Brazil | ||
| Hospital of Clinics of the University Federal of Minas Gerais |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28918167 | Derived | Mauricio SF, Xiao J, Prado CM, Gonzalez MC, Correia MITD. Different nutritional assessment tools as predictors of postoperative complications in patients undergoing colorectal cancer resection. Clin Nutr. 2018 Oct;37(5):1505-1511. doi: 10.1016/j.clnu.2017.08.026. Epub 2017 Sep 4. |
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Scientific publications
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
| D011183 | Postoperative Complications |
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
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Samples of abdominal rectal muscles.
| Belo Horizonte |
| Minas Gerais |
| Brazil |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D012816 | Signs and Symptoms |