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Surgical stress and anesthesia may cause immunosuppression in immunocompromised cancer patients. The natural killer (NK) cell is a critical part of anti-tumor immunity. Dexmedetomidine has sympatholytic effect and preserves NK cell function. This study investigate the effect of dexmedetomidine on immune suppression and postoperative outcomes in patients undergoing uterine cancer resection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dexmedetomidine Group | Experimental | dexmedetomidine infusion (0.4 mcg/kg/h) from immediately after anesthetic induction to 24 h after surgery |
|
| Control Group | Placebo Comparator | 0.9% saline infusion |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidine group | Drug | dexmedetomidine infusion (0.4 mcg/kg/h) from immediately after anesthetic induction to 24 h after surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| natural killer cell cytotoxicity | Natural killer cell cytotoxicity is measured with NK Vue Kitâ„¢(ATGen, Gyeonggi-do, Korea). | 1 minute before surgery |
| natural killer cell cytotoxicity | Natural killer cell cytotoxicity is measured with NK Vue Kitâ„¢(ATGen, Gyeonggi-do, Korea). | postoperative day 1 |
| natural killer cell cytotoxicity | Natural killer cell cytotoxicity is measured with NK Vue Kitâ„¢(ATGen, Gyeonggi-do, Korea). | postoperative day 3 |
| natural killer cell cytotoxicity | Natural killer cell cytotoxicity is measured with NK Vue Kitâ„¢(ATGen, Gyeonggi-do, Korea). | postoperative day 5 |
| Measure | Description | Time Frame |
|---|---|---|
| inflammatory response | inflammatory response is assessed by measuring levels of proinflammatory cytokines. | 1 minute before surgery |
| inflammatory response | inflammatory response is assessed by measuring levels of proinflammatory cytokines. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine | Seoul | 03722 | South Korea |
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| Control group | Drug | 0.9% saline infusion |
|
| postoperative day 1 |
| inflammatory response | inflammatory response is assessed by measuring levels of proinflammatory cytokines. | postoperative day 3 |
| inflammatory response | inflammatory response is assessed by measuring levels of proinflammatory cytokines. | postoperative day 5 |
| ID | Term |
|---|---|
| D014594 | Uterine Neoplasms |
| ID | Term |
|---|---|
| D005833 | Genital Neoplasms, Female |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D014591 | Uterine Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
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| ID | Term |
|---|---|
| D035061 | Control Groups |
| ID | Term |
|---|---|
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
| D008722 | Methods |
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