Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose is to compare and evaluate multiple functional imaging methods (perfusion, diffusion, spectroscopy) for initial benign/malignant characterization of osteoarticular tumors and to determine which method or which association of methods could improve non invasive tissue characterization.
Secondary purposes are:
The ancillary study will enroll patients needing radiological tumor follow-up. The purpose is to identify tools for evaluation of tumor activity and therapeutic response before modification of morpho-volumetric data.
Patients refered for the initial evaluation of suspected osteoarticular masses will be included in this study after signing an informed consent.
Histologic analysis will be used as a gold standard.
The following imaging techniques will be evaluated:
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with bone or peripheral soft-tissue tumor | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ecography | Other | Standard Doppler ultrasound and perfusion imaging after injection of Sonovue |
|
| Measure | Description | Time Frame |
|---|---|---|
| Contrast enhancement in echography: yes or no | baseline | |
| Contrast enhancement curve (absent, slow or fast) in echography | baseline | |
| Maximal intensity of enhancement peak in echography | baseline | |
| Mean transit time of enhancement in echography | baseline | |
| Gradient of contrast enhancement curve in echography | baseline | |
| Vascularization (dynamic analysis) in CT scanner |
| baseline |
| Contrast enhancement curve (absent, slow or fast) in CT scanner | baseline | |
| Maximal intensity of enhancement peak in CT scanner | baseline | |
| Mean transit time of enhancement in CT scanner | baseline | |
| Gradient of contrast enhancement curve in CT scanner | baseline | |
| Contrast enhancement curve (absent, slow or fast) in MRI |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Pedro Augusto GONDIM TEIXEIRA | Contact | ped_gt@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Pedro Augusto GONDIM TEIXEIRA | Service d'Imagerie Guilloz, CHRU Nancy | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service d'Imagerie Guilloz, CHRU Nancy | Recruiting | Nancy | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33765161 | Derived | Ribeiro GJ, Gillet R, Hossu G, Trinh JM, Euxibie E, Sirveaux F, Blum A, Teixeira PAG. Solitary bone tumor imaging reporting and data system (BTI-RADS): initial assessment of a systematic imaging evaluation and comprehensive reporting method. Eur Radiol. 2021 Oct;31(10):7637-7652. doi: 10.1007/s00330-021-07745-9. Epub 2021 Mar 25. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D001859 | Bone Neoplasms |
| D012983 | Soft Tissue Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| CT scan | Other | With injection of Iomeron 400 |
|
| MRI | Other | With injection of gadolinium (Multihance) |
|
| baseline |
| Maximal intensity of enhancement peak in MRI | baseline |
| Mean transit time of enhancement in MRI | baseline |
| Gradient of contrast enhancement curve in MRI | baseline |
| Choline peak in magnetic resonance spectroscopy | Choline presence was defined as a clear metabolite peak at 3.2 ppm | baseline |
| Apparent diffusion coefficient (ADC) in MR diffusion weighted imaging | ADC value in mm2/s | baseline |
| Area under the perfusion curve in MRI | baseline |
| Perfusion curve gradient in MRI | baseline |
| Perfusion time-to-peak in MRI | baseline |