Osteoarticular Tumor Characterization by Advanced Imaging

Osteoarticular Tumor Characterization by Advanced Imaging

The purpose is to compare and evaluate multiple functional imaging methods (perfusion, diffusion, spectroscopy) for initial benign/malignant characterization of osteoarticular tumors and to determine which method or which association of methods could improve non invasive tissue characterization.

Secondary purposes are:

• to determine a possible correlation between some parameters and the histological grade (FNCLCC)
• to suggest a coherent diagnostic imaging approach for osteoarticular tumors.

The ancillary study will enroll patients needing radiological tumor follow-up. The purpose is to identify tools for evaluation of tumor activity and therapeutic response before modification of morpho-volumetric data.

Patients refered for the initial evaluation of suspected osteoarticular masses will be included in this study after signing an informed consent.

Histologic analysis will be used as a gold standard.

The following imaging techniques will be evaluated:

• contrast enhanced ultrasonography
• Low dose CT perfusion
• Magnetic resonance perfusion
• Diffusion weighted imaging
• Magnetic resonance proton spectroscopy

Inclusion Criteria:

• patients examined for initial assessment of bone or peripheral soft-tissue primitive tumor
• patients with normal awareness level
• patients having signed informed consent

Exclusion Criteria:

• pregnant women
• persons deprived of liberty
• persons under legal protection or unable to give informed consent
• persons in life-threatening emergency
• allergy to Sonovue, iodinated contrast media or gadolinium chelates
• risk of pregnancy
• breastfeeding women
• acute coronary syndrome or unstable ischemic cardiopathy (ban on injection of contrast agent for CT scan)
• renal failure (ban on injection of contrast agent for MRI and CT scan)
• contraindication to MRI