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| Name | Class |
|---|---|
| University Hospital, Lille | OTHER |
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Study on quantitative perfusion parameters acquired on MR imaging of patients with non-tumoral pathology of the musculoskeletal system.
Patients referred for the MR imaging evaluation of non-tumoral musculoskeletal pathology (osteonecrosis, pseudarthrosis and compartment syndrome) will have their MR protocols complemented by a contrast enhanced perfusion study. In this patients standard clinical evaluation is already performed with contrast medium injection (Gadolinium) and no additional injection is required.
After post processing multiple quantitative perfusions parameters will be extracted (e.g. plasmatic volume, transfer constant, backflow constant, extra-cellular extra vascular space volume). The variation of these parameters in patients with and without the previously described conditions will be compared.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal patients | Experimental | Patients with normal bone appearance on conventional MR images |
|
| Carpal osteonecrosis | Experimental | Patients presenting signal anomalies compatible with osteonecrosis of the carpal bones on conventional MR images (hypointensity on T1 weighted sequences, no contrast enhancement). |
|
| Femoral head osteonecrosis | Experimental | Patients presenting signal anomalies compatible with osteonecrosis of the femoral head on conventional MR images (fat containing signal anomalies with geographic contours in the femoral epiphysis). |
|
| Pseudarthrosis | Experimental | Patients presenting a non consolidated macroscopic bone fracture for over 6 months (clinical history and imaging findings). |
|
| Compartment syndrome | Experimental | Patients with a confirmed compartment syndrome on intra-compartment pressure assessement |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| T1 mapping and MR perfusion acquisition | Other | One T1 mapping acquisition with variable flip angles will be performed before contrast injection. One perfusion 3D FSPGR sequence will be acquired after contrast injection |
| Measure | Description | Time Frame |
|---|---|---|
| Variation of the plasmatic volume estimation in the 5 study groups (arms) and between the images acquired in the two inclusion sites. | The plasmatic volume (Vp%) in ml is a quantitative perfusion parameter that describes the capillar density of the tissues evaluated and can be useful in tissue characterization | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| Variation of the plasma-extra-cellular space transfer constant in the 5 study groups (arms) and between the images acquired in the two inclusion sites. | The plasma-extracellular space transfer constant (Ktrans) in min -1 is a quantitative perfusion parameter that is related to the capillar permeability and blood flow. This parameter can be useful for tissue characterization. | 3 years |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Pedro TEIXEIRA, MD, PhD | Contact | 33 (3) 83 85 21 61 | ped_gt@hotmail.com | |
| Gabriela Hossu, PhD | Contact | 33 (3) 83 15 50 96 | g.hossu@chru-nancy.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CCIAL, CHRU-Lille | Recruiting | Lille | Hauts-de-France | 59036 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25129825 | Background | Mueller D, Schaeffeler C, Baum T, Walter F, Rechl H, Rummeny EJ, Woertler K. Magnetic resonance perfusion and diffusion imaging characteristics of transient bone marrow edema, avascular necrosis and subchondral insufficiency fractures of the proximal femur. Eur J Radiol. 2014 Oct;83(10):1862-9. doi: 10.1016/j.ejrad.2014.07.017. Epub 2014 Jul 30. | |
| 23188589 |
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| ID | Term |
|---|---|
| D010020 | Osteonecrosis |
| D011542 | Pseudarthrosis |
| D003161 | Compartment Syndromes |
| ID | Term |
|---|---|
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D009336 | Necrosis |
| D010335 | Pathologic Processes |
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| Variation of the extra-cellular space-plasma transfer constant (backflow constant) in the 5 study groups (arms) and between the images acquired in the two inclusion sites. | The extracellular-space-plasma transfer constant or backflow constant (Kep) in min -1 is a quantitative perfusion parameter that is related to the capillar permeability. This parameter can be useful for tissue characterization. | 3 years |
| Variation of the extra-cellular extra-vascular space volume in the 5 study groups (arms) and between the images acquired in the two inclusion sites. | The extracellular-space extra-vascular space volume (Ve%) in ml is a quantitative perfusion parameter that is related to the tissue cellularity. This parameter can be useful for tissue characterization. | First 6 months of inclusion |
| Service d'Imagerie Guilloz, CHRU-Nancy | Recruiting | Nancy | Lorraine | 54000 | France |
|
| Muller GM, Mansson S, Muller MF, Ekberg O, Bjorkman A. Assessment of perfusion in normal carpal bones with dynamic gadolinium-enhanced MRI at 3 Tesla. J Magn Reson Imaging. 2013 Jul;38(1):168-72. doi: 10.1002/jmri.23951. Epub 2012 Nov 27. |
| 25398469 | Background | Bervian MR, Ribak S, Livani B. Scaphoid fracture nonunion: correlation of radiographic imaging, proximal fragment histologic viability evaluation, and estimation of viability at surgery: diagnosis of scaphoid pseudarthrosis. Int Orthop. 2015 Jan;39(1):67-72. doi: 10.1007/s00264-014-2579-4. Epub 2014 Nov 16. |
| 15067424 | Background | Rominger MB, Lukosch CJ, Bachmann GF. MR imaging of compartment syndrome of the lower leg: a case control study. Eur Radiol. 2004 Aug;14(8):1432-9. doi: 10.1007/s00330-004-2305-5. Epub 2004 Apr 6. |
| 23695220 | Result | Teixeira PA, Chanson A, Beaumont M, Lecocq S, Louis M, Marie B, Sirveaux F, Blum A. Dynamic MR imaging of osteoid osteomas: correlation of semiquantitative and quantitative perfusion parameters with patient symptoms and treatment outcome. Eur Radiol. 2013 Sep;23(9):2602-11. doi: 10.1007/s00330-013-2867-1. Epub 2013 May 22. |
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D005599 | Fractures, Ununited |
| D050723 | Fractures, Bone |
| D014947 | Wounds and Injuries |
| D009135 | Muscular Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |