Not provided
Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| 2012-A01009-34 | Other Identifier | ID-RCB number, ANSM |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The mechanism of bone loss in anorexia nervosa is complex. Marrow adipose tissue seems to play a role in the regulation of bone metabolism. Adipocytes secrete cytokines and adipokines that either stimulate or inhibit adjacent osteoblasts. This study consist to explore the relationship in anorexia nervosa patients with change in bone mineral density and adipokines like leptin, adiponectin and Préf-1 Bone mineral densities will be measure in 180 anorexia nervosa patients at inclusion and every two years during 6 years.It is assessed blood and urinary calcium and phosphate levels, bone remodelling markers and adipokines (leptin, adiponectin and Préf-1)
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Anorexia patient | Dual Energy X-ray Absorptiometry (DEXA) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| DEXA | Device | The Dual Energy X-ray Absorptiometry (DEXA) is a third generation multi-captor DEXA device that allow short duration measurements. It measures Bone Mineral Density (BMD) at the spine and the femoral neck |
| Measure | Description | Time Frame |
|---|---|---|
| Bone mineral density by Dual Energy X-ray Absorptiometry (DEXA) | measured the evolution of the bone mineral density in 180 anorexia nervosa patients and the relationship with this change and adipokine | 4 years |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of osteoporotic fractures | at 2,4 and 6 years | |
| Adiponectin plasma concentration by ELISA | measurement of circulating biological factors predicative of changes in BMD | at 2,4 and 6 years |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Anorexia patient recruted in psychiatric unit ( hospitalisation and consultation visit)
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Isabelle LEGROUX, MD | University Hospital, Lille | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Roger Salengro, CHRU de Lille | Lille | France |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D000856 | Anorexia Nervosa |
| D010024 | Osteoporosis |
| ID | Term |
|---|---|
| D001068 | Feeding and Eating Disorders |
| D001523 | Mental Disorders |
| D001851 | Bone Diseases, Metabolic |
| D001847 | Bone Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
| Interleukin-7 plasma concentration by ELISA | measurement of circulating biological factors predicative of changes in BMD | at 2,4 and 6 years |
| D009140 |
| Musculoskeletal Diseases |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |