Bone Loss in Patients With Anorexia Nervosa

Physiopathology of Bone Loss in Young Patient With Anorexia Nervosa

Nutritional deprivation of adolescent girls with anorexia nervosa (AN) reduces the bone mass acquisition. A better understanding of this process would improve the medical treatment of bone alteration and its long-term consequences.

160 patients (age < 38 yr) with AN and 160 age-matched controls (CON) will be enrolled in this study. The areal bone mineral density (aBMD) will be determined using dual-X-ray absorptiometry. Calciotropic hormones, bone turnover markers will be concomitantly evaluated.

Inclusion Criteria:

• Informed Consent
• Health Insurance regimen or benefit from an health insurance regimen
• Aged from 14 to 38 years old
• Women
• No pregnant

Specific inclusion criteria for patient:

Patient suffering from anorexia nervosa defined by criteria of Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)

Specific inclusion criteria for controls:

• Normal menstrual cycles,
• No lifetime history of eating disorders,
• BMI between 18 and 25 kg/m²

Exclusion Criteria:

• use of treatments may be modify bone mass (bisphosphonates,…)
• Disease or treatment may be induce osteoporosis
• In exclusion period in relation with another study
• Law protected subject