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Nutritional deprivation of adolescent girls with anorexia nervosa (AN) reduces the bone mass acquisition. A better understanding of this process would improve the medical treatment of bone alteration and its long-term consequences.
160 patients (age < 38 yr) with AN and 160 age-matched controls (CON) will be enrolled in this study. The areal bone mineral density (aBMD) will be determined using dual-X-ray absorptiometry. Calciotropic hormones, bone turnover markers will be concomitantly evaluated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with anorexia nervosa | Experimental | This arm is the experimental arm composed of patients |
|
| controls subjects | Active Comparator | This arm is composed of healthy volunteers |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| clinical parameters description | Other | description of weight, height, Bone Mass Index, dietary questionnary, amenorrhea time, pathology time for the two arms |
|
| Measure | Description | Time Frame |
|---|---|---|
| Dual-X-ray absorptiometry (DEXA) | The primary outcome is to model the bone mass acquisition in young women with anorexia nervosa. | at Day 0 (time of the inclusion visit) |
| Measure | Description | Time Frame |
|---|---|---|
| Biological parameters identification | One of the secondary outcome is to identify biological factors associated with bone demineralisation. | At day 0 (time of the inclusion visit) |
| clinical parameters identification |
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Inclusion Criteria:
Specific inclusion criteria for patient:
Patient suffering from anorexia nervosa defined by criteria of Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
Specific inclusion criteria for controls:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Patrick PL LEFEBVRE, MD | University Hospital, Montpellier | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Montpellier - Département d'Endocrinologie Diabète | Montpellier | 34295 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26245848 | Result | Maimoun L, Guillaume S, Lefebvre P, Philibert P, Bertet H, Picot MC, Gaspari L, Paris F, Seneque M, Dupuys AM, Courtet P, Thomas E, Mariano-Goulart D, Bringer J, Renard E, Sultan C. Evidence of a link between resting energy expenditure and bone remodelling, glucose homeostasis and adipokine variations in adolescent girls with anorexia nervosa. Osteoporos Int. 2016 Jan;27(1):135-46. doi: 10.1007/s00198-015-3223-x. Epub 2015 Aug 6. | |
| 26418163 |
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| ID | Term |
|---|---|
| D000856 | Anorexia Nervosa |
| ID | Term |
|---|---|
| D001068 | Feeding and Eating Disorders |
| D001523 | Mental Disorders |
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| para clinical parameters description | Other | description of DMO, mass, basal metabolism, IGF-1/IGFBP-3 for the two arms |
|
| hormonal parameters dosing | Other | dosing of leptine, leptine receptor, adiponectine, ghreline for the two arms |
|
| bone modeling markers dosing | Other | dosing of osteocalcine, bone alkalin phosphatase, C-telopeptide of type-I collagene, osteoprotegerine/ RANKL for the two arms |
|
One of the secondary outcome is to identify the clinical factors associated with bone demineralisation.
| At Day 0 (at time of the the inclusion visit) |
| Result |
| Maimoun L, Guillaume S, Lefebvre P, Philibert P, Bertet H, Picot MC, Courtet P, Mariano-Goulart D, Renard E, Sultan C. Is Serum Serotonin Involved in the Bone Loss of Young Females with Anorexia Nervosa? Horm Metab Res. 2016 Mar;48(3):174-177. doi: 10.1055/s-0035-1559632. Epub 2015 Sep 29. |
| 24471564 | Result | Maimoun L, Guillaume S, Lefebvre P, Philibert P, Bertet H, Picot MC, Gaspari L, Paris F, Courtet P, Thomas E, Mariano-Goulart D, Bringer J, Renard E, Sultan C. Role of sclerostin and dickkopf-1 in the dramatic alteration in bone mass acquisition in adolescents and young women with recent anorexia nervosa. J Clin Endocrinol Metab. 2014 Apr;99(4):E582-90. doi: 10.1210/jc.2013-2565. Epub 2014 Jan 28. |