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The purpose is to evaluate the reproducibility of neuromuscular monitoring data of recovery from neuromuscular blockade, obtained with TOFScan® and TOF-Watch SX®, in adult and pediatric population.
Secondary purposes are to evaluate the reproducibility of data obtained with 2 monitors for:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Adult population 1 | Other | TOF-Watch SX® on nondominant arm and TOFScan® on dominant arm |
|
| Adult population 2 | Other | TOF-Watch SX® on dominant arm and TOFScan® on nondominant arm |
|
| Pediatric population 1 | Other | TOF-Watch SX® on nondominant arm and TOFScan® on dominant arm |
|
| Pediatric population 2 | Other | TOF-Watch SX® on dominant arm and TOFScan® on nondominant arm |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Rocuronium | Drug | Anesthesia induction with Propofol and maintaining with desflurane. For adult patients, the curare is rocuronium (0.6 mg/kg) For pediatric patients, the curare can be rocuronium (0.6 mg/kg), cisatracurium (0.1 mg/kg) or atracurium (0.5 mg/kg) |
| Measure | Description | Time Frame |
|---|---|---|
| Time of recovery of the first (T1) response of train of four monitoring displayed on TOFScan and on TOF Watch SX | day 0, after induction of anesthesia | |
| Time of recovery of the second (T2) response of train of four monitoring displayed on TOFScan and on TOF Watch SX | day 0, after induction of anesthesia | |
| Time of recovery of the third (T3) response of train of four monitoring displayed on TOFScan and on TOF Watch SX | day 0, after induction of anesthesia | |
| Time of recovery of the fourth (T4) response of train of four monitoring displayed on TOFScan and on TOF Watch SX | day 0, after induction of anesthesia | |
| Time of recovery of T4/T1 of train of four monitoring at 40% of initial value displayed on TOFScan and on TOF Watch SX | day 0, after induction of anesthesia | |
| Time of recovery of T4/T1 of train of four monitoring at 60% of initial value displayed on TOFScan and on TOF Watch SX | day 0, after induction of anesthesia | |
| Time of recovery of T4/T1 of train of four monitoring at 90% of initial value displayed on TOFScan and on TOF Watch SX | day 0, after induction of anesthesia | |
| Time of recovery of T4/T1 of train of four monitoring at 100% of initial value displayed on TOFScan and on TOF Watch SX | day 0, after induction of anesthesia |
| Measure | Description | Time Frame |
|---|---|---|
| Time of suppression of the first response of train of four monitoring (T1) at 95% initial value displayed on TOFScan and on TOF Watch SX | day 0, after induction of anesthesia | |
| Time of recovery of the first response of train of four monitoring (T1) to 25% initial value displayed on TOFScan and on TOF Watch SX |
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Inclusion Criteria:
Adult population:
Pediatric population:
Exclusion Criteria:
Adult population:
Pediatric population:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Thomas FUCHS-BUDER, Pr | Contact | t.fuchs-buder@chru-nancy.fr |
| Name | Affiliation | Role |
|---|---|---|
| Thomas FUCHS-BUDER, Pr | CHRU de NANCY - Hôpitaux de Brabois - Département d'Anesthésie-Réanimation - VANDOEUVRE LES NANCY - FRANCE | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHRU de NANCY - Hôpitaux de Brabois - Département d'Anesthésie-Réanimation | Recruiting | Vandœuvre-lès-Nancy | France |
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| Neuromuscular monitoring with TOFScan® and TOF-Watch SX® | Device | Each monitor on one arm |
|
| day 0, after induction of anesthesia |
| ID | Term |
|---|---|
| D000077123 | Rocuronium |
| D061886 | Neuromuscular Monitoring |
| ID | Term |
|---|---|
| D000732 | Androstanols |
| D000731 | Androstanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D008991 | Monitoring, Physiologic |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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