Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Assistance Publique Hopitaux De Marseille | OTHER |
| University Hospital, Clermont-Ferrand | OTHER |
| Assistance Publique - Hôpitaux de Paris | OTHER |
Not provided
Not provided
Not provided
Not provided
Significant cognitive impairment (executive functions, memory, attention) is common in schizophrenia affecting up to 80% of patients. But pharmacological treatments (typical and atypical antipsychotic) do not have impact on cognitive functioning. For over 20 years, alternative non-pharmacological therapeutics have been developed in schizophrenia. These techniques called cognitive remediation specifically target cognitive deficits. The first cognitive remediation available for patients was designed to stimulate new learning, or relearning, of cognitive tasks, and thus to improve certain deficient domains. These procedures were efficient in improving cognition as measured by neurocognitive tests but their impact on functioning and daily life was weak. In a second time, compensatory remediation has been developed. Compensatory approaches seek to make improvements in the patient's functioning by avoiding areas of impairment and recruiting other intact cognitive domains or by creating a supportive external environment. In recent meta-analysis compensatory remediation has larger effect-size than classical cognitive remediation, with an impact on patients psychosocial functioning. Recently, Dr E. Twamley (University of California) developed and tested a group-based, manualized, compensatory cognitive training intervention.
Compensatory cognitive training (CCT) is a low-tech, brief intervention and is easily transposable in community care. Our team translated this method into French. The investigators planned a cost -utility study between CCT and treatment as usual in schizophrenia patients with less than 10 years of evolution.
This study will take place over 3 years with a recruitment period of 18 months. After verification of the eligibility criteria and signature of the consent, the patients will be divided into 2 groups by randomization: the intervention group and the control group. The duration of participation of the subjects will be 12 months. Assessments are available in 4 steps (V1 at inclusion, V2 at 3 months, V3 at 6 months and V4 at 12 months). These visits include an assessment of the functioning of patients, symptomatology, quality of life, treatment and care received at all visits, occupational activity and cognitive assessment and social knowledge at V1 and V4.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Compensatory cognitive training | Experimental | Compensatory cognitive training |
|
| usual treatment | Placebo Comparator | usual treatment for shizophrenai |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Compensatory cognitive training | Other | In addition to the usual care, method of compensatory cognitive remediation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cost-utility questionnaire | Cost difference between the 2 group of patients | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Functioning questionnaire | FROGS, Functional Remission of General Schizophrenia | 3 months |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Delphine DC CAPDEVIELLE, MD-PhD | Montpellier University Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Charles Perrens Hospital | Bordeaux | 33076 | France | |||
| Le Vinatier Hospital |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
Not provided
Not provided
| Hôpital Louis Mourier |
| OTHER |
| Centre Hospitalier Charles Perrens, Bordeaux | OTHER_GOV |
| University Hospital, Strasbourg | OTHER |
| Hospital Center Alpes-Isère | OTHER |
| Hôpitaux à Bron | OTHER |
| Fondation FondaMental | OTHER |
Not provided
Not provided
Not provided
Not provided
Not provided
| Usual | Other | Usual care |
|
| Bron |
| 69678 |
| France |
| Gabriel-Montpied Univesity Hospital | Clermont-Ferrand | 63003 | France |
| Louis Mourier Hospital | Colombes | 92701 | France |
| Chenevier Hospital | Créteil | 94000 | France |
| La Conception Hospital | Marseille | 13005 | France |
| Montpellier University Hospital | Montpellier | 34295 | France |
| Alpes Isère Hospital | Saint-Égrève | 38521 | France |
| Strasbourg University Hospital | Strasbourg | 67091 | France |