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The purpose is to characterize the change of respiratory admittance induced by salbutamol inhalation in children and young adults. A variation threshold will be fixed to distinguish asthmatic and healthy subjects.
This project could allow a better identification of asthmatic individuals needing a treatment, a reduction of morbidity of asthma, a reduction of unnecessary treatments administered in individuals with respiratory but not asthmatic symptoms, a better comprehension of bronchial hyperreactivity and its role in asthmatic disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Asthma child | Experimental |
| |
| Control adult | Experimental |
| |
| Control child | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Salbutamol | Drug | bronchodilation obtained with 2 inhalations of salbutamol (100 µg per dose) with inhalation chamber |
|
| Measure | Description | Time Frame |
|---|---|---|
| Ventilatory mechanical impedance | Measured with Forced oscillation technique. 2 measures at basal status at 10 min interval for reproducibility and after 10 min broncodilation with salbutamol | day 0 |
| Thoracic gas volume | Measured with Plethysmography. | day 0 |
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Inclusion Criteria:
Asthmatic children group:
Control children group:
- Parental authorization and consent of child to participate to the study
Control adult group:
- Consent to participate to the study
Exclusion Criteria:
Control children and adult groups:
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| Name | Affiliation | Role |
|---|---|---|
| François MARCHAL | CHU de Nancy - Hôpital BRABOIS Enfants - Explorations fonctionnelles pédiatriques | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Nancy - Hôpital BRABOIS Enfants - Explorations fonctionnelles pédiatriques | Vandœuvre-lès-Nancy | France |
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| ID | Term |
|---|---|
| D001249 | Asthma |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
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| ID | Term |
|---|---|
| D000420 | Albuterol |
| ID | Term |
|---|---|
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
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|
| Forced oscillation technique | Procedure | before and after bronchodilation |
|
| Plethysmography | Procedure |
|
| D012130 |
| Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D000588 |
| Amines |
| D010627 | Phenethylamines |
| D005021 | Ethylamines |