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Obstructive Sleep Apnea Syndrome (OSAS) regardless of any other associated risk factor can lead to accelerated aging. The study of aging-related Obstructive Sleep Apnea (OSA) is difficult because of associated risk factors (diabetes, hypertension, dyslipidemia, obesity), promoting themselves aging. The investigators propose to compare a group of OSAS patients free of any associated pathology, to subjects matched for age, sex, smoking and body mass index (BMI)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Severe OSA | Other | Patients with severe OSA (AHI > 30) |
|
| Moderate OSA | Other | Patients with moderate OSA (5 < AHI ≤ 30) |
|
| Healthy volunteers | Other | Healthy volunteers (AHI ≤ 5) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Polysomnography , blood collection, bone densitometry and Functional respiratory explorations | Other | Blood collection, Bone densitometry and Functional respiratory explorations are a specific interventions of protocol for the 3 arms. Polysomnography is a specific intervention for the arms " healthy volunteers " |
| Measure | Description | Time Frame |
|---|---|---|
| Telomere length of circulating leukocytes | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Carotid-femoral pulse wave velocity | 4 weeks | |
| Bone density | 4 weeks | |
| Correlation between biological parameters and neuropsychological assessment |
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Inclusion Criteria
Patient:
Healthy volunteers:
Exclusion Criteria
All subjects:
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| Name | Affiliation | Role |
|---|---|---|
| Laurent Boyer, MD | Assistance Publique - Hôpitaux de Paris | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Henri Mondor Hospital | Créteil | 94010 | France |
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| ID | Term |
|---|---|
| D020181 | Sleep Apnea, Obstructive |
| ID | Term |
|---|---|
| D012891 | Sleep Apnea Syndromes |
| D001049 | Apnea |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
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|
| 4 weeks |
| Markers of oxidative stress: Malondialdehyde, heme oxygenase-1 | 4 weeks |
| Markers of inflammation: hs-CRP, IL-6, IL-8, MCP-1 | 4 weeks |
| Markers of growth hormone axis (GH, IGF-1, IGFBP) | 4 weeks |
| D020919 |
| Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |