A Pilot Investigation Detecting Cryoablation Scar by 3D Late Gadolinium Enhancement

A Pilot Investigation Detecting Cryoablation Scar by 3D Late Gadolinium

This is a prospective trial investigating the effectiveness of a modified MRI preparatory pulse sequence to improve pulmonary vein isolation visualization.

Inclusion Criteria:

• Men or non-pregnant women
• A diagnosis of symptomatic paroxysmal or recently persistent atrial fibrillation with a documented successful cardioversion within 4 months of the procedure
• Documented treatment failure or intolerance of at least 1 anti-arrhythmic medication used to control atrial fibrillation.

Exclusion Criteria:

• Contraindication to MRI, such as implanted incompatible metal prosthesis, or subject size exceeds bore or table limits
• Allergy to gadolinium-based contrast agent
• Previous atrial fibrillation ablation
• Renal dysfunction (estimated GFR <60 mL/min/1.73m2) within 6 months
• Unwilling to provide informed consent for this protocol