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| Name | Class |
|---|---|
| Utah State University | OTHER |
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The purpose of the study is to determine the effects of both an anthocyanin-rich polyphenol blend and an anthocyanin-rich polyphenol blend combined with a prebiotic blend on fecal microbiota metabolism (assessed by gas chromatograph - mass spectrometry (GC-MS) headspace analysis) and fecal microbiota composition (assessed by next generation sequencing).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo,Flavonoids,Flavonoids+Prebiotics | Experimental | Participants will receive three treatments, for three weeks each, with 21 day washout period between each product. |
|
| Placebo,Flavonoids+Prebiotics,Flavonoids | Experimental | Participants will receive three treatments, for three weeks each, with 21 day washout period between each product. |
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| Flavonoids,Placebo,Flavonoids+Prebiotics | Experimental | Participants will receive three treatments, for three weeks each, with 21 day washout period between each product. |
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| Flavonoids,Flavonoids+Prebiotics,Placebo | Experimental | Participants will receive three treatments, for three weeks each, with 21 day washout period between each product. |
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| Flavonoids+Prebiotics,Placebo,Flavonoids |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo | Other | A combination of maltodextrins and red and blue food colors. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in fecal volatile methyl sulfides at day 21, day 63, day 105 | assessed by gas chromatograph - mass spectrometry (GC-MS) headspace analysis | baseline, day 21, day 63, day 105 |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in all fecal VOCs at day 21, day 63, day 105 | baseline, day 21, day 63, day 105 | |
| Change from baseline fecal short chain fatty acids at day 21, day 63, day 105 | baseline, day 21, day 63, day 105 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Michael Lefevre, PhD | Utah State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Utah State University | Logan | Utah | 84322 | United States |
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| ID | Term |
|---|---|
| D005419 | Flavonoids |
| ID | Term |
|---|---|
| D002867 | Chromones |
| D001578 | Benzopyrans |
| D011714 | Pyrans |
| D006573 | Heterocyclic Compounds, 1-Ring |
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Participants will receive three treatments, for three weeks each, with 21 day washout period between each product. |
|
| Flavonoids+Prebiotics,Flavonoids,Placebo | Experimental | Participants will receive three treatments, for three weeks each, with 21 day washout period between each product. |
|
| Flavonoids | Dietary Supplement | A combination of blueberry extract, black current extract, and black rice extract. |
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| Flavonoids+Prebiotics | Dietary Supplement | A combination of blueberry extract, black current extract, black rice extract, inulin, and fructooligosaccharide. |
|
| Change from baseline fecal microbiota composition at day 21, day 63, day 105 | baseline, day 21, day 63, day 105 |
| D006571 |
| Heterocyclic Compounds |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |