Circulating And Intra-Tumoral Chemokines In Patients With Prostate Cancer

Study Of The Expression Of Circulating And Intra-Tumoral Chemokines In Patients With Prostate Cancer

Multicentric, observational, prospective, non-interventional study with occasional biological sample collection (serum bank, urine bank and tumor bank)

This project is an exploratory study, based on the hypothesis of involvement of chemokines in hormonal escape of prostate cancers.

The two main objectives are:

• To describe the variations in expression of chemokines in serum and urine level in patients with prostate cancer
• And to study the disease stage and intra-prostatic concentrations of chemokines based on serum and urine concentrations of chemokines before treatment initiation.

These estimates can be used in future trials set up for the management of prostate cancer

Inclusion Criteria:

• Patients with a localized or metastatic prostate adenocarcinoma for which a new treatment will be implemented (hormone therapy for single biological relapse or relapses and metastatic hormone-sensitive) or chemotherapy (for biological relapses and / or metastatic hormone-resistant)
• Patients with a detectable PSA (Prostate-Specific Antigen)
• Patients who signed an informed consent
• Patients over 18 years
• Patients belonging to the social security scheme

Exclusion Criteria:

• Active Hepatitis B or C virus
• HIV positive
• Patients who have received prior chemotherapy
• Patients with a second neoplasia treated in the last 5 years