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Despite novel treatment options, Renal Cell Carcinoma (RCC) has been characterized by a constant increase in its mortality and consequently requires an important involvement in translational research.
The aim of this study is to evaluate the interest of CXCL4, CXCL4L1 and CXCR3 as biomarkers in localized, locally advanced or metastatic RCC. Indeed these chemokines have shown anti-angiogenic and anti-tumor properties in experimental models and may be particularly interesting for prognostic and predictive purposes.
Based on a physiopathological rationale, the use of RCC-directed antiangiogenic therapies into clinical practice leads to conclusive results and makes RCC a particularly well-suited tumor type to study factors involved in the angiogenic process. Furthermore the intensive use of targeted therapies in clinical practice raised new questions about their management.
Therefore the identification of new molecular biomarkers is important:
Low CXCL4, CXCL4L1 and CXCR3 tumor expression levels are associated with bad prognosis factors in RCC. Consequently their interest in RCC is worth being evaluated, in two subgroups : Localized / locally advanced renal cell carcinoma and Metastatic renal cell carcinoma.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A. Surgically treated patients | Patients having a radical or partial nephrectomy. |
| |
| Group B. Patients treated with targeted therapies | Patients treated by RCC-directed targeted therapy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Biological sample | Biological | 2 blood samples of 10mL + one urine sample
|
| Measure | Description | Time Frame |
|---|---|---|
| Prognostic value of the markers of interest (CXCL4, CXCL4L1 et CXCR3) | Prognostic value of the markers of interest (CXCL4, CXCL4L1 et CXCR3) will be evaluated by the association of these markers with time to event occurrence. Localized or locally advanced renal cell carcinoma group:
Metastatic renal cell carcinoma group :
| 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| Predictive value of therapeutic response | Predictive value of therapeutic response will be assessed for patients receiving systemic therapy. It will be evaluated by the association of markers of interest with the therapeutic response.
|
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Inclusion Criteria:
Patients diagnosed with localized, locally advanced or metastatic Renal Cell Carcinoma :
Patients who have signed and dated an informed consent form with the investigator
Exclusion Criteria:
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Patients diagnosed with localized, locally advanced or metastatic Renal Cell Carcinoma
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| Name | Affiliation | Role |
|---|---|---|
| Jean-Christophe BERNHARD, Dr | University Hospital Bordeaux, France | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Bordeaux Hospital | Bordeaux | 33076 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
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| 17489332 |
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| ID | Term |
|---|---|
| D002277 | Carcinoma |
| D002292 | Carcinoma, Renal Cell |
| D007680 | Kidney Neoplasms |
| D007674 | Kidney Diseases |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D000230 | Adenocarcinoma |
| D014571 | Urologic Neoplasms |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D014570 | Urologic Diseases |
| ID | Term |
|---|---|
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
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whole blood, urine and tissues
|
| Biological sample | Biological | 2 blood samples of 10mL + one urine sample
|
|
| 3 years |
| Background |
| Raynal G, Bernhard JC. [Premature death from urologic cancer: the kidneys at the forefront]. Prog Urol. 2007 Apr;17(2):260-1. doi: 10.1016/s1166-7087(07)92277-0. No abstract available. French. |
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| 1695112 | Background | Eisman R, Surrey S, Ramachandran B, Schwartz E, Poncz M. Structural and functional comparison of the genes for human platelet factor 4 and PF4alt. Blood. 1990 Jul 15;76(2):336-44. |
| 15459074 | Background | Struyf S, Burdick MD, Proost P, Van Damme J, Strieter RM. Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis. Circ Res. 2004 Oct 29;95(9):855-7. doi: 10.1161/01.RES.0000146674.38319.07. Epub 2004 Sep 30. |
| 17575164 | Background | Struyf S, Burdick MD, Peeters E, Van den Broeck K, Dillen C, Proost P, Van Damme J, Strieter RM. Platelet factor-4 variant chemokine CXCL4L1 inhibits melanoma and lung carcinoma growth and metastasis by preventing angiogenesis. Cancer Res. 2007 Jun 15;67(12):5940-8. doi: 10.1158/0008-5472.CAN-06-4682. |
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