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Alleviating pain in children undergoing renal transplant is extremely challenging. Large incisions as those of renal transplant (Gibson's incision) require special techniques of pain control that don't affect hemodynamics or renal function. Since the transplant incision doesn't cross midline; a dual-TAP block is thought to be effective in providing pain control in such procedure as it will anesthetize the dermatomes T6-T12, the muscles of the anterior abdominal wall together with the underlying parietal peritoneum.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| dual TAB group | Active Comparator | 22 patients will receive unilateral dual transversus abdominis plane (TAB) block USING bupivacaine 0.25% at a dose of 2 mg/kg |
|
| control group | Sham Comparator | 22 patients who will not receive dual TAB block |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| bupivacaine | Drug | bupivacaine 0.25% at a dose 2 mg/kg in the transversus abdominis plane |
| |
| Measure | Description | Time Frame |
|---|---|---|
| total dose of rescue analgesia | pethidine given as rescue analgesia postoperative. | from the time of transfer of the patient to the intensive care unit at one hour intervals for 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| pain scoring system (objective behavioural pain score) | from the time of transfer to the nephrology ICU, every hour for the first 24 hours postoperative | |
| Intraoperative blood pressure | measure systolic and diastolic blood pressure |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sherif M Soaida, M.D. | Cairo University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of medicine, Cairo University | Cairo | 11562 | Egypt |
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| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D010146 | Pain |
| ID | Term |
|---|---|
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| ID | Term |
|---|---|
| D002045 | Bupivacaine |
| D008614 | Meperidine |
| D005283 | Fentanyl |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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| Pethidine |
| Drug |
pethidine intravenous at a dose 1mg/kg when pain score more than 5 postoperative rescue analgesia |
|
| perfalgan | Drug | intravenous paracetamol |
|
| fentanyl | Drug |
|
| from the induction of anesthesia till end of surgery at half an hour intervals average duration is 4 hours |
| postoperative blood pressure | record systolic and diastolic blood pressure every hour for the first 24 hours postoperative | from the time of transfer of the patient to the intensive care unit at one hour intervals for 24 hours |
| postoperative heart rate | from the time of transfer of the patient to the intensive care unit at one hour intervals for 24 hours |
| intraoperative heart rate | from the induction of anesthesia till end of surgery at half an hour intervals average duration is 4 hours |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D000588 |
| Amines |
| D007540 | Isonipecotic Acids |
| D000147 | Acids, Heterocyclic |
| D006571 | Heterocyclic Compounds |
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |