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| Name | Class |
|---|---|
| University of Lausanne Hospitals | OTHER |
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This study aims at investigating the acute influence of artificially sweetened beverages consumption (as compared with sugar-sweetened beverages and water consumption) on brain responses to the viewing of food images, on physiological responses (gut-derived hormones and lipid metabolites) and on the food intake behavior.
This study is made on a randomized controlled crossover design including three conditions (water, sugar, artificial sweeteners). Measurements will be performed in fasting and fed conditions. The test-meal will comprise either an artificially or sugar-sweetened beverage or water (control). The spatio-temporal brain dynamics to the viewing of food pictures will be assessed by means of electroencephalography (EEG) recordings and electrical neuroimaging analyses. Venous blood and urine will be collected. Blood pressure, cardiac frequency and bio-impedance measurements will be performed. Food intake behavior will be assessed by means of questionnaires and a free-choice buffet. Each tested condition (water, sugar, artificial sweeteners) will be preceded by a run-in period during which the participants' diet will be controlled (2-day isoenergetic diet).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Artificial sweetener | Experimental | Effects of co-ingestion of artificially sweetened beverage on the response to a test meal |
|
| Sugar | Active Comparator | Effects of co-ingestion of sugar-sweetened beverage on the response to a test meal |
|
| Water | Active Comparator | Effects of co-ingestion of water on the response to a test meal |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ingestion of a test meal with sweetener | Other | participants will ingest a test meal containing 55% carbohydrate, 30% fat and 15% protein with artificially sweetened drinks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Spatio-temporal brain dynamics | Spatio-temporal brain dynamics to the viewing of food will be assessed by means of electroencephalography recordings. | differences observed between 60 min before and 60 min after ingestion of a test meal |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in concentration of blood insulin | Blood substrate concentration will be measured in fasting conditions and after ingestion of a test meal | -120 min before ingestion of a test meal, and 30, 60, 90, 150, and 210 min after ingestion of a test meal |
| Changes in concentration of blood triglyceride |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Luc Tappy, Professor | Department of Physiology, University of Lausanne, Switzerland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Physiology | Lausanne | Canton of Vaud | 1005 | Switzerland |
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| ID | Term |
|---|---|
| D013549 | Sweetening Agents |
| D014867 | Water |
| ID | Term |
|---|---|
| D005421 | Flavoring Agents |
| D005503 | Food Additives |
| D000074385 | Food Ingredients |
| D020313 | Specialty Uses of Chemicals |
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| ingestion of a test meal with sweetener | Other | participants will ingest a test meal containing 55% carbohydrate, 30% fat and 15% protein with sugary drinks drinks |
|
| ingestion of a test meal with water | Other | participants will ingest a test meal containing 55% carbohydrate, 30% fat and 15% protein with waters |
|
Blood substrate concentration will be measured in fasting conditions and after ingestion of a test meal |
| -120 min before ingestion of a test meal, and 30, 60, 90, 150, and 210 min after ingestion of a test meal |
| Changes in concentration of blood Fibroblast Growth Factor (FGF)-21 | Blood substrate concentration will be measured in fasting conditions and after ingestion of a test meal | -120 min before ingestion of a test meal, and 30, 60, 90, 150, and 210 min after ingestion of a test meal |
| spontaneous food intake | Food intake behavior will be assessed by monitoring spontaneous food intake when offered a free-choice buffet. | 240 min after ingestion of a test meal |
| D020164 |
| Chemical Actions and Uses |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |
| D006878 | Hydroxides |
| D000468 | Alkalies |
| D007287 | Inorganic Chemicals |
| D000838 | Anions |
| D007477 | Ions |
| D004573 | Electrolytes |
| D010087 | Oxides |
| D017601 | Oxygen Compounds |