Urinary Markers of Detrusor Overactivity in Spina Bifida Patients

Urinary Markers of Detrusor Overactivity in Spina Bifida Patients

The purpose of this study is to assess diagnostic performance of urinary markers of detrusor overactivity (Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF), adenosine triphosphate (ATP), Prostaglandine E2) in detected high pressure bladder un spina bifida patients.

Inclusion Criteria:

Study arm:

• Spina bifida patient
• Seen consecutively in outpatient clinics
• Age > 18 years-old

Control arm:

• Patients with multiple sclerosis or spinal cord injury or overactive bladder
• Seen consecutively in urodynamics
• with lower urinary tract symptoms
• Age > 18 years-old

Exclusion Criteria:

• Positive urine culture
• History of urologic neoplasms
• History of interstitial cystitis