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| Name | Class |
|---|---|
| King's College Hospital NHS Trust | OTHER |
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To determine the appropriate volume (size) of ventilator breath during volume-targetted ventilation for infants born with congenital diaphragmatic hernia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 4, 5, 6ml/kg targetted tidal volume | Experimental | Randomised to receive TTV at 4ml/kg, 5ml/kg, 6ml/kg. Measurement of PTPdi |
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| 4, 6, 5ml/kg targetted tidal volume | Experimental | Randomised to receive TTV at 4ml/kg, 6ml/kg, 5ml/kg. Measurement of PTPdi |
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| 5, 4, 6ml/kg targetted tidal volume | Experimental | Randomised to receive TTV at 5ml/kg, 4ml/kg, 6ml/kg. Measurement of PTPdi |
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| 5, 6, 4ml/kg targetted tidal volume | Experimental | Randomised to receive TTV at 5ml/kg, 6ml/kg,4ml/kg. Measurement of PTPdi |
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| 6, 5, 4ml/kg targetted tidal volume | Experimental |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Measurement of PTPdi | Device | Insertion of pressure transducer catheter to measure gastic and oesophadgeal pressures for calculation of PTPdi |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in Pressure Time Product of the diaphragm (PTPdi) at different levels of targetted tidal volume | PTPdi will be measured at each level of tidal volume. The outcome measure is the change in PTPdi. | 3 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Katie Hunt, MA, MBBS | Contact | 00442032999000 | 38492 | katie.a.hunt@kcl.ac.uk |
| Name | Affiliation | Role |
|---|---|---|
| Anne Greenough, MD, MBBS | King's College London | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| King's College Hospital | Recruiting | London | SE59RS | United Kingdom |
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| ID | Term |
|---|---|
| D065630 | Hernias, Diaphragmatic, Congenital |
| ID | Term |
|---|---|
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D006548 | Hernia, Diaphragmatic |
| D000082122 | Internal Hernia |
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Randomised to receive TTV at 6ml/kg, 5ml/kg, 4ml/kg. Measurement of PTPdi
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| 6, 4, 5ml/kg targetted tidal volume | Experimental | Randomised to receive TTV at 6ml/kg, 4ml/kg, 5ml/kg. Measurement of PTPdi |
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| TTV at 4ml/kg | Device | Provision of targetted tidal volume of 4ml/kg |
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| TTV at 5ml/kg | Device | Provision of targetted tidal volume of 5ml/kg |
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| TTV at 6ml/kg | Device | Provision of targetted tidal volume of 6ml/kg |
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| D006547 | Hernia |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |