Volume Targeted Mask Ventilation Versus Pressure Ventilation in Preterm Infants

Volume Targeted Mask Ventilation Versus Pressure Ventilation in Preterm Infants

This is a pilot trial to assess the feasibility of volume Targeted Ventilation in the Delivery Room.

Preterm infants will be randomized to pressure guided or volume targeted ventilation during respiratory support in the delivery room

Inclusion Criteria:

• Born between 23+0/7 to 28+6/7 weeks' gestation
• Considered suitable for full resuscitation, i.e., no parental request or antenatal decision to forego resuscitation
• Informed parental consent

Exclusion Criteria:

• Major congenital or chromosomal malformation
• Conditions that might have an adverse effect on breathing or ventilation (e.g., high risk for lung hypoplasia, congenital diaphragmatic hernia)
• Congenital heart disease requiring intervention in the neonatal period
• Hydrops requiring intervention in the neonatal period
• Neonatal resuscitation initiated before NICU team arrival
• Infants who are born outside of study center and transported to center after delivery