Inflammatory Markers and Resistant Depression

Inflammatory Markers and Resistant Depression

This study focuses on blood inflammatory markers (pro-inflammatory cytokines, anti-inflammatory cytokines, monocytes costimulation molecules) in patients with resistant unipolar depression in comparison with non-resistant unipolar depressed patients.

Inclusion Criteria:

• group 1: Patients with resistant MDD (at least 2 failed treatments for the current episode) ,current treatment with IRS or IRSNA,
• group 2: patients with MDD remission after response to an antidepressant treatment.

Exclusion Criteria:

• comorbid somatic or psychiatric disorders: chronic or acute inflammatory diseases, previous treatment with brain stimulation for the current episode, legal protection