Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This study focuses on blood inflammatory markers (pro-inflammatory cytokines, anti-inflammatory cytokines, monocytes costimulation molecules) in patients with resistant unipolar depression in comparison with non-resistant unipolar depressed patients.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| resistant depression | Other | patients suffering from resistant unipolar depression (at least 2 failed antidepressant treatments for the current episode) |
|
| non resistant depression | Other | patients in remission from unipolar depressive disorder |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| blood sample | Procedure | blood sample for concentration levels of inflammatory markers |
|
| Measure | Description | Time Frame |
|---|---|---|
| plasmatic concentration of Interleukin 6 | at patient inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| concentration of proinflammatory cytokine | Expression intensity of monocytes costimulation molecules | at patient inclusion |
| concentration of antiinflammatory cytokine | at patient inclusion |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Emmanuel Haffen, MD PhD | Contact | 0033381218388 | ehaffen@chu-besancon.fr | |
| Julie Monnin, PhD | Contact | 0033381218543 | jmonnin@chu-besancon.fr |
| Name | Affiliation | Role |
|---|---|---|
| Emmanuel Haffen, MD PhD | CHU Besançon | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Besançon | Besançon | 25000 | France |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D003863 | Depression |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
Not provided
Not provided
| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| psychometric scales | Behavioral | Mini international interview MADRS, C-SSRS, QIDS-SR, BIS-10, BDHI, BART, ERD |
|
| functional polymorphisms of expression genes of inflammatory proteins | at patient inclusion |
| plasmatic concentration of Retinoid X receptor signaling pathway | at patient inclusion |
| Expression rate of monocytes costimulation molecules | at patient inclusion |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |