Blood Biomarkers in Major Depression

Blood Biomarkers in Major Depression

Depression is a leading cause of disability worldwide, affecting nearly 16% of the general population. Its physiopathology remains unclear. Based on gene-environment studies and epigenetic studies, a main hypothesis proposed that the major depressive episode (MDE) results from the convergence of multiple factors including biological factors such as multi-genic vulnerability, hormonal and immunological variations as well as environmental factors. As a consequence, mRNA could define a biological signature of the MDE.

Inclusion Criteria:

• Major depressive disorder at inclusion according to the DSM IV at the time of the inclusion,

  • Having a score on the scale of depression of Hamilton ( HDRS-17) > 19 at the time of the inclusion,
  • Taken care by a grown-up psychiatric department, that the coverage(care) is realized in ambulatory or during a hospitalization

Exclusion Criteria:

• Schizophrenia