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Background: Postoperative cognitive dysfunction (POCD) in elderly patients after noncardiac surgery is a common problem.
Therefore,this study was designed to assess POCD after closed-loop coadministration of propofol and remifentanil guided by bispectral index in comparison to intravenous anesthesia in elderly patients undergoing major noncardiac surgery. Methods: After approval of the local ethical committee was obtained, 204 patients (American Society of Anesthesiologists physical status I-III; age, > 55 yr) undergoing surgery (duration, > 1 h) were enrolled into this pospective randomized monocenter study. Patients received anesthesia 3 days after using a neuropsychological test battery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| INTRAVENOUS ANESTHESIA | Experimental | neuropsychological test battery |
|
| CLOSED LOOP ANESTHESIA | Experimental | neuropsychological test battery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| neuropsychological test battery | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| the incidence of early POCD in elderly patients (aged 55 yrs or older) | 3 DAYS |
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Inclusion Criteria:
Exclusion Criteria:
-
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| E SAMAIN, PR | Contact | 03 81 66 85 79 | ||
| Lucie VETTORETTI | Contact | lvettoretti@chu-besancon.fr |
| Name | Affiliation | Role |
|---|---|---|
| E SAMAIN, PR | Centre Hospitalier Universitaire de Besancon | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chu Besancon | Recruiting | Besançon | 25000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30290615 | Derived | Besch G, Vettoretti L, Claveau M, Boichut N, Mahr N, Bouhake Y, Liu N, Chazot T, Samain E, Pili-Floury S. Early post-operative cognitive dysfunction after closed-loop versus manual target controlled-infusion of propofol and remifentanil in patients undergoing elective major non-cardiac surgery: Protocol of the randomized controlled single-blind POCD-ELA trial. Medicine (Baltimore). 2018 Oct;97(40):e12558. doi: 10.1097/MD.0000000000012558. |
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