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| ID | Type | Description | Link |
|---|---|---|---|
| 2012-005270-61 | Other Identifier | eudraCTNumber |
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The recovery of cognitive and psychomotor functions is best performed under anesthesia after desflurane when propofol in that obtaining a Aldrete score> 8/10 output of the allowing SSPI.
The principal objective is to compare the cognitive and psychomotor status of patients recovered an Aldrete score> 8/10 according to the anesthetic agent (propofol or desflurane) using three tests (Stroop test, Digit Symbol Substitution task and a test of verbal memory (visual verbal learning test) made SSPI.
The day before surgery, patients sign the consent and will be randomized. Then 3 tests (Stroop test, Digit Symbol Substitution Task and visual verbal learning test) will be performed. No anxiolysis will be given to the patient. The anesthetic induction will be with IV propofol (2-3 mg / kg). The maintenance will anesthetic, desflurane by for a minimum alveolar concentration of between 2% and 6% or propofol for intravenous anesthesia user target controlled. In SSPI, the Aldrete score will be evaluated every 5min. Upon obtaining a Aldrete score> 8/10, the day before the tests will be carried out again
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Propofol | Experimental | Intraoperative anesthetic strategy by Propofol versus Desflurane |
|
| Desflurane | Experimental | Intraoperative anesthetic strategy by Desflurane versus Propofol |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intraoperative anesthetic strategy by Propofol | Drug | 1- Arm Propofol: Propofol TCI induction target between 2 and 6 mg / mL
|
| Measure | Description | Time Frame |
|---|---|---|
| Compare the cognitive and psychomotor status of patients recovered an Aldrete score> 8/10 according to the anesthetic agent (propofol or desflurane) | Compare the cognitive and psychomotor status of patients recovered an Aldrete score> 8/10 according to the anesthetic agent (propofol or desflurane), using three tests (Stroop test, Digit Symbol Substitution Task and test verbal memory (visual verbal learning test) made room post-interventional monitoring The primary endpoint will be the average score of three tests in room post-interventional monitoring (Stroop test, Digit Symbol Substitution Task, Visual Verbal Learning Test) scores expressed in standard deviation | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| proportion of patients with nausea and vomiting | 1 day | |
| Search intraoperative factors alterations in cognitive and psychomotor functions (number of red blood cells transfused, number of hypotensive episodes (≤ 80mmHg or MAP NOT ≤ 65mmHg)≥ 10 minutes). |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Cyrille Robert, PH | APHP | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Saint Antoine | Paris | Paris | 75012 | France |
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| Intraoperative anesthetic strategy by Desflurane | Drug | 2- Arm Desflurane Desflurane induction (2-3 mg / kg)
|
|
| 1 day |
| Evaluate patient satisfaction on a visual analogue scale in room post-interventional monitoring | 1 day |
| Evaluate postoperative pain in room post-interventional monitoring | 1 day |