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The purpose of this study is to explore the therapeutic effect and mechanism of transcranial magnetic stimulation (rTMS) in the treatment of the tardive dyskinesia.
The study was a parallel control design trial for 2 weeks. Patients with schizophrenia were treated with 10-Hz rTMS on left motor cortex (added to the ongoing treatment). Clinical symptoms and MEP were assessment before and after rTMS treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| tardive dyskinesia group | Active Comparator | tardive dyskinesia group will be delivered at an intensity that is 80% of the resting motor threshold (RMT). Stimulation will be delivered at 10 Hz with 60 stimulation trains of 30 stimuli each (i.e., 1800 stimuli) and an intertrain interval of 12 sec in primary motor cortex（M1）. |
|
| Healthy control group | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Repetitive Transcranial Magnetic Stimulation | Device | Stimulate the primary motor cortex for 2 weeks. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in motor evoked potential(MEP) | 2 times (Before treatment,immediately after treatment) | |
| Change from baseline in Abnormal Involuntary Movement Scale(AIMS） | 2 times (Before treatment,immediately after treatment) |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in cortical silent period | 2 times (Before treatment,immediately after treatment) | |
| Change from baseline in short interval intracortical inhibition(SICI） | 2 times (Before treatment,immediately after treatment) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dengtang Liu | Contact | +86 21 64387250-73775 | erliu110@126.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine | Recruiting | Shanghai | Shanghai Municipality | 200030 | China |
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| ID | Term |
|---|---|
| D000071057 | Tardive Dyskinesia |
| ID | Term |
|---|---|
| D004409 | Dyskinesia, Drug-Induced |
| D020820 | Dyskinesias |
| D009069 | Movement Disorders |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D050781 | Transcranial Magnetic Stimulation |
| ID | Term |
|---|---|
| D055909 | Magnetic Field Therapy |
| D013812 | Therapeutics |
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| Change from baseline in intracortical facilitation(ICF） | 2 times (Before treatment,immediately after treatment) |
| Change from baseline in Simpson-Angus Scale（SAS） | 2 times (Before treatment,immediately after treatment) |
| Change from baseline in Barnes Akathisia Rating Scale（BARS） | 2 times (Before treatment,immediately after treatment) |
| Change from baseline in Positive and Negative Syndrome Scale（PANSS） | 2 times (Before treatment,immediately after treatment) |
| Change from baseline in clinical global impression (CGI) | 2 times (Before treatment,immediately after treatment) |
| D009422 | Nervous System Diseases |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |