Repetitive Transcranial Magnetic Stimulation for the Treatment of the Tardive Dyskinesia.

Repetitive Transcranial Magnetic Stimulation for the Treatment of the Tardive Dyskinesia.

The purpose of this study is to explore the therapeutic effect and mechanism of transcranial magnetic stimulation (rTMS) in the treatment of the tardive dyskinesia.

The study was a parallel control design trial for 2 weeks. Patients with schizophrenia were treated with 10-Hz rTMS on left motor cortex (added to the ongoing treatment). Clinical symptoms and MEP were assessment before and after rTMS treatment.

Inclusion Criteria:

• The diagnosis of schizophrenia according to DSM-IV；
• At least two item of Abnormal Involuntary Movement Scale（AIMS） must be 2 points or higher
• these symptoms are not from Parkinson，tourette's syndrome,huntington disease
• Signed an informed consent

Exclusion Criteria:

• rTMS contraindications: intracranial metal substance, with heart pacemakers and cochlear implants, intracranial pressure
• patients to be diagnosed according to DSM-IV for substance abused, development delayed
• current treatment with anticonvulsant acting drugs such as anticonvulsants, benzodiazepines
• Acute risk of suicide and impulse
• history of epileptic seizures or the presence of epileptic activity documented on the basis of EEG
• pregnant and lactant women