Arterial calcification is an independent predictor of coronary events associated with a 3-4 fold increased risk of cardiovascular events. Currently, no effective intervention exists to reduce arterial calcification. However, recent studies showed that vitamin K may reduce ongoing calcium deposition in the arteries, and thereby inhibit arterial calcification.

The primary objective is to determine if MK-7 supplementation leads to stabilization or attenuation of ongoing calcium deposition in the femoral artery as quantified by 18F-NaF PET/CT imaging in patients with type 2 diabetes and arterial disease.

Inclusion Criteria:

• Middle aged men and women, ≥ 40 years.
• Diagnosed with type 2 diabetes.
• Presence of arterial diseases, based on an Ankle Brachial Index (ABI) <0.9 and/or diagnosed with arterial diseases by physician.
• ABI<0.9
• Written informed consent.

Exclusion Criteria:

• Subjects participate in another intervention research or study using imaging.
• Contra-indication for undergoing18F-NaF PET/CT scan (claustrophobia, pregnancy, breastfeeding).
• Subject underwent amputation of the lower extremities (above the knee).
• Using vitamin K antagonists.
• Known coagulation problems (history of Venous Thrombo Embolism).
• Using vitamin supplements that contain vitamin K, or unwilling to stop two weeks before randomisation.
• A mean vitamin K2 intake ≥120 microgram/day measured with a questionnaire.
• Natto or goose liver consumers.
• Low kidney function (eGFR<30).