Investigations of the Effect of MK-7 on Bone and Glucose Metabolism and Arterial Calcification

Investigations of the Effect of MK-7 on Bone and Glucose Metabolism and Arterial Calcification

The aims of the present study are to investigate the effect of vitamin K2 on bone turnover, bone mass, bone structure, glucose metabolism, and arteriosclerosis.

Osteoporosis, diabetes, metabolic syndrome and cardiovascular disease are common diseases that affect large groups of people in the Western world.

Our hypotheses is that vitamin K2 (MK-7) reduces undercarboxylated osteocalcin in postmenopausal women and reduces bone turnover and increases bone mineral density; increases insulin sensitivity and decreases indices of arterial calcification.

Osteoporosis, diabetes, metabolic syndrome and cardiovascular disease are common diseases that affect large groups of people in the Western world.

Our hypotheses is that vitamin K2 (MK-7) reduces undercarboxylated osteocalcin in postmenopausal women and reduces bone turnover and increases bone mineral density; increases insulin sensitivity and decreases indices of arterial calcification.

Inclusion Criteria:

• postmenopausal women
• 60-80 years
• osteopenia

Exclusion Criteria:

• Calcium metabolic, thyroid, liver or kidney disease
• Diabetes
• Obesity
• Myocardial infarction or other arteriosclerotic events
• Angina pectoris
• Vitamin D < 50 nmol/L
• Treatment with vitamin K antagonists
• Use of vitamin K supplements in the last month or for more than 3 months at any time
• Treatment with drugs with known effects on bone metabolism or glucose metabolism.
• Smoking in the last 12 months
• Drug or alcohol abuse
• Allergy to calcium, vitamin D or vitamin K.