Clinical Assessment of Perfusion Techniques During Repair of Coarctation With Aortic Arch Hypoplasia in Infants

Clinical Assessment of Perfusion Techniques During Surgical Repair of Coarctation of Aorta With Aortic Arch Hypoplasia in Infants

The purpose of this study is to evaluate safety and efficacy of three main perfusion methods in surgical repair of coarctation of aorta with aortic arch hypoplasia in infants.

Three perfusion techniques of visceral protection will be assessed - deep hypothermic circulatory arrest, selective antegrade cerebral perfusion and double arterial cannulation (perfusion of brachiocephalic artery with thoracic descending aorta by two arterial cannulas)

Inclusion Criteria:

• coarctation with severe aortic arch hypoplasia (distal aortic arch z-score < -2)
• coarctation of aorta with septal defects

Exclusion Criteria:

• coarctation with mild aortic arch hypoplasia (distal aortic arch z-score > -2)
• complex congenital heart diseases including aortic arch hypoplasia (e.g. transposition of great arteries, double oulet right ventricle, atrioventricular septal defect, Shone's complex)
• univentricular and duct-dependent heart defects
• aortic valve and/or mitral valve stenosis/hypoplasia (aortic valve or mitral valve z-score < -2.0)
• left ventricular dysfunction (left ventricle ejection fraction < 60%)
• congenital renal or central nervous system anomalies
• related infectious diseases
• prematurity (gestational age < 37 weeks)