Cerebral Perfusion in Hypothermic Circulatory Arrest

Cerebral Perfusion During Cardiac Surgery With Hypothermic Circulatory Arrest

Selective antegrade cerebral perfusion (sACP) during aortic arch surgery in hypothermic circulatory arrest (HCA) is an established method for intraoperative neuroprotection. Although sACP is established as a beneficial method to reduce secondary neurological side effects due to brain-malperfusion, there are several parameters like sACP flow rate, perfusion pressure or temperature of the perfusate, where the optimal values remain unclear. The flow rate of the sACP-perfusate is increased according to center-specific standard-procedures. The optimal sACP flow rate, monitored by near infrared spectroscopy (NIRS), is to be investigated in this single center clinical prospective observational study. 40 Patients are enrolled over an estimated period of 14 months.

Inclusion Criteria:

• Age 18 years or older
• Elective cardiac surgery with cardiopulmonary bypass
• Hypothermic circulatory arrest
• General informed consent signed

Exclusion Criteria:

- Severe stenotis in cerebral arteries