The Canadian E-PAraDiGM (Exercise Physical Activity and Diabetes Glucose Monitoring) Protocol

The Canadian E-PAraDiGM (Exercise Physical Activity and Diabetes Glucose Monitoring) Protocol

Walking is encouraged for people with type 2 diabetes but there is little evidence that performing a bout of walking can improve glucose control. Furthermore, it is unknown how participant characteristics (e.g., age, sex, medications) impact the acute glucose responses to walking in people with type 2 diabetes. The primary purpose of this study is to examine how a standardized bout of walking impacts glucose control assessed over 24 hours using continuous glucose monitoring. A secondary purpose is to determine whether responses are influenced by age, sex, and medication use.

Inclusion Criteria:

• Diagnosed with T2D for more than 6 months
• 30-90 years of age
• No contra-indications to exercise (PAR-Q+, Rose Angina questionnaire, limited ability to walk for 50 min).
• No previous myocardial infarction, stroke or diagnosed coronary artery disease
• No changes in diabetes medication in last 3 months
• Not treated by insulin or corticosteroids
• No significant change in body weight (>5%) in last 3 months
• Blood pressure <160/100 mmHg; resting HR<100
• Able to understand English or French and comply with study requirements (e.g., attend visits during the day)
• Hemoglobin A1C <9.0%
• No prior history of hypoglycaemia during activity or sleep

Exclusion Criteria:

• Chest pain during physical activity.
• Chest pain while resting (no physical activity) in the past month.
• Loss of balance or consciousness because of dizziness in past 12 months
• Bone or joint problem (for example, back, knee, or hip) that could be made worse by a change in physical activity.
• Currently pregnant or planning on becoming pregnant in the next 3 months
• Currently taking exogenous insulin
• Previous heart attack or stroke
• Any other reason that prevents ability to walk on a treadmill for 50 minutes