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| Name | Class |
|---|---|
| University of Yaounde 1 | OTHER |
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This study was aimed at assessing the effects of non-surgical periodontal treatment (NSPT) of chronic periodontitis on insulin sensitivity, glucose tolerance, and serum C-reactive protein(CRP) level amongst non-diabetic subjects.
Subjects with chronic periodontitis will undergo non-surgical periodontal treatment (NSPT) consisting of a complete scaling, polishing, root planning, and the irrigation of periodontal pockets with a 10% povidone iodine solution. Periodontal parameters (plaque index, gingival bleeding index, pocket depth, and clinical attachment loss), insulin sensitivity using KITT, glucose tolerance using oral glucose tolerance test and serum CRP level by immunoturbidimetry will be measured before and 3 months after the NSPT.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| non-surgical periodontal treatment | Experimental | One session of non-surgical periodontal treatment consisting of a complete scaling, polishing, root planning, and the irrigation of periodontal pockets with a 10% povidone iodine solution. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| non-surgical periodontal treatment | Procedure | One session of complete scaling, polishing, root planning, and the irrigation of periodontal pockets with a 10% povidone iodine solution |
| Measure | Description | Time Frame |
|---|---|---|
| Glucose tolerance | change in 2-hour post load blood glucose | 3 months |
| Insulin sensitivity | change in glucose disappearance rate during the short insulin tolerance test | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Composite periodontal health | Change in plaque index, gingival bleeding index, pocket depth, and clinical attachment loss | 3 months |
| Inflammation | change in Serum CRP |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Eugene Sobngwi, MD, PhD | University of Yaoundé 1 and Yaoundé Central Hospital | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34261767 | Derived | Nana Nana AR, Tsobgny Tsague NF, Lontchi-Yimagou E, Bengondo Messanga C, Tankeu A, Katte JC, Balti Vounsia E, Dehayem M, Sobngwi E. Effects of non-surgical treatment of chronic periodontitis on insulin resistance and glucose tolerance in subjects without diabetes (PARODIA 2 study). J Investig Med. 2021 Oct;69(7):1377-1381. doi: 10.1136/jim-2021-001831. Epub 2021 Jul 14. |
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| ID | Term |
|---|---|
| D010518 | Periodontitis |
| D011236 | Prediabetic State |
| D003920 | Diabetes Mellitus |
| D018149 | Glucose Intolerance |
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D044882 | Glucose Metabolism Disorders |
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| 3 months |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D006943 | Hyperglycemia |
| D006946 | Hyperinsulinism |