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Therapeutic hypothermia after out-of-hospital cardiac arrest is considered as a standard care. However, optimal candidates, optimal dose, duration, timing of initiation and rate of rewarming is still unknown. The objective of this project is to improve the outcomes for patients after resuscitation from out-of-hospital cardiac arrest treated with therapeutic hypothermia established from the analysis of multicenter registry data.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| not provided | Other |
| Measure | Description | Time Frame |
|---|---|---|
| survival | 6 months after cardiac arrest | |
| Neurologic Outcome | Cerebral Performance Category (CPC). CPC 1,2 : Good Outcome CPC 3,4,5 : Poor Outcome | 6 months after cardiac arrest |
| Neurologic Outcome | modified Rankin Scale (mRS) mRS 0,1,2, 3 : Good Outcome mRS 4,5,6 : Poor Outcome | after 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| survival | duration of hospitalization, limit 180 days | |
| neurological outcome | Cerebral Performance Category (CPC). CPC 1,2 : Good Outcome CPC 3,4,5 : Poor Outcome | duration of hospitalization, limit 180 days |
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Inclusion Criteria:
Exclusion Criteria:
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patients treated with therapeutic hypothermia after out-of-hospital cardiac arrest.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kyu Nam Park, MD, PhD | Contact | 82-2-2258-6301 | emsky@catholic.ac.kr |
| Name | Affiliation | Role |
|---|---|---|
| Kyu Nam Park, MD. PhD | Seoul St. Mary's Hospital, The Catholic University of Korea | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul St. Mary's Hospital, The Catholic University of Korea | Recruiting | Seoul | 06591 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37559163 | Derived | Kim YJ, Kim YH, Youn CS, Cho IS, Kim SJ, Wee JH, Park YS, Oh JS, Lee BK, Kim WY. Different neuroprognostication thresholds of neuron-specific enolase in shockable and non-shockable out-of-hospital cardiac arrest: a prospective multicenter observational study in Korea (the KORHN-PRO registry). Crit Care. 2023 Aug 9;27(1):313. doi: 10.1186/s13054-023-04603-6. | |
| 31521016 |
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| ID | Term |
|---|---|
| D058687 | Out-of-Hospital Cardiac Arrest |
| ID | Term |
|---|---|
| D006323 | Heart Arrest |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| neurological outcome | modified Rankin Scale (mRS) mRS 0,1,2, 3 : Good Outcome mRS 4,5,6 : Poor Outcome | duration of hospitalization, limit 180 days |
| Survival | 1 month after cardiac arrest |
| neurological outcome | Cerebral Performance Category (CPC). CPC 1,2 : Good Outcome CPC 3,4,5 : Poor Outcome | 1 month after cardiac arrest |
| neurological outcome | modified Rankin Scale (mRS) mRS 0,1,2, 3 : Good Outcome mRS 4,5,6 : Poor Outcome | 1 month after cardiac arrest |
| Oh JH, Lee DH, Cho IS, Youn CS, Lee BK, Wee JH, Cha KC, Chae MK, Shin J; Korean Hypothermia Network Investigators. Association between acute kidney injury and neurological outcome or death at 6 months in out-of-hospital cardiac arrest: A prospective, multicenter, observational cohort study. J Crit Care. 2019 Dec;54:197-204. doi: 10.1016/j.jcrc.2019.08.029. Epub 2019 Aug 28. |