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| Name | Class |
|---|---|
| University of Notre Dame | OTHER |
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This project will characterize lower extremity eccentric muscle function among individuals who have undergone locomotor training after spinal cord injury and will evaluate the effect of downhill training at slow to moderate speeds - targeted to rehabilitation eccentric function of the hip and knee.
Lower extremity eccentric motor control is is critically important for locomotor function but is impaired after spinal cord injury (SCI). Even after treadmill training, preliminary evidence indicates that eccentric deficits persist among individuals with SCI. This proposal aims to characterize eccentric motor control of the muscles about the hip and knee during locomotion and evaluate the efficacy of downhill gait training at slow speeds as an intervention to improve eccentric function of the hip joint and knee joint during walking.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Individuals with no spinal cord injury or other neurological deficits. | ||
| Untrained and Trained SCI Hip and Knee | Individuals with spinal cord injury who have been discharged from a locomotor training program at least 6 months prior to enrollment in this study. Untrained individuals will complete 3 baseline measures and then complete eccentric training which will focus on rehabilitation of the hip joint or knee joint. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Untrained and Trained SCI Hip or Knee | Behavioral | Individuals with SCI will perform downhill walking training 3 times a week for 12 wks with a 4 wk follow-up period. This intervention will be delivered by trained therapists. In order to focus on rehabilitation of hip control or knee control, members of this group will be trained at slow to moderate gait speeds, |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in time to complete 6 minutes of level walking (i.e., the 6 minute walk test) | baseline, 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in time to complete 10 meters of level walking (i.e., the 10 meter walk test) | baseline, 12 weeks | |
| Change from baseline in peak magnitude of frontal hip loading response as measured by the peak magnitude of frontal hip power absorption during the weight acceptance phase of walking |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in Neuromuscular Recovery Scale score | baseline, 12 weeks | |
| Change from baseline in balance function as measured by the Berg Balance Scale score | baseline, 12 weeks | |
Individuals with SCI:
Inclusion Criteria:
Exclusion Criteria:
Note: Use of anti-spasticity and other medications (dose, frequency) will be monitored throughout training and used as a confounding variable in the analyses.
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Individuals from the community that are healthy and without musculoskeletal or orthopedic impairments will serve as healthy case-controls. The individuals with chronic spinal cord injury will come from outpatient clinic referrals and former participants in locomotor training rehabilitation programs.
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| Name | Affiliation | Role |
|---|---|---|
| D. Michele M Basso | Ohio State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Ohio State University | Columbus | Ohio | 43210 | United States |
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| ID | Term |
|---|---|
| D013119 | Spinal Cord Injuries |
| ID | Term |
|---|---|
| D013118 | Spinal Cord Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020196 | Trauma, Nervous System |
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| baseline, 12 weeks |
| Change from Baseline in SCI specific Quality of Life score |
| baseline, 12 weeks |
| Change from second baseline in time to complete 6 minutes of level walking (i.e., the 6 minute walk test) | 12 weeks, 16 weeks |
| Change from second baseline in time to complete 10 meters of level walking (i.e., the 10 meter walk test) | 12 weeks, 16 weeks |
| Change from second baseline in peak magnitude of frontal hip loading response as measured by the peak magnitude of frontal hip power absorption during the weight acceptance phase of walking | 12 weeks, 16 weeks |
| Change from second baseline in quadriceps eccentric contraction capacity as measured by difference in maximum voluntary eccentric knee flexion contraction before and after eccentric exercise targeting the contralateral quadriceps | 12 weeks, 16 weeks |
| Change from second baseline in Neuromuscular Recovery Scale score | 12 weeks, 16 weeks |
| Change from second baseline in balance function as measured by Berg Balance Scale score | 12 weeks, 16 weeks |
| Change from second baseline in SCI specific Quality of Life score | 12 weeks, 16 weeks |
| D014947 | Wounds and Injuries |