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| Name | Class |
|---|---|
| University of Notre Dame | OTHER |
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This project will characterize lower extremity eccentric muscle function among individuals who have undergone locomotor training after spinal cord injury and will evaluate the effect of downhill training at moderate speeds - targeted to rehabilitation eccentric function of the knee or hip.
Lower extremity eccentric motor control is is critically important for locomotor function but is impaired after spinal cord injury (SCI). Even after treadmill training, preliminary evidence indicates that eccentric deficits persist among individuals with SCI. This proposal aims to characterize eccentric motor control of the muscles about the knee or hip during locomotion and evaluate the efficacy of downhill gait training at moderate speeds as an intervention to improve eccentric function of the knee joint or hip joint during walking.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | No Intervention | Individuals with no spinal cord injury or other neurological deficits. | |
| Unexercised SCI Knee or Hip | No Intervention | Individuals with spinal cord injury who have been discharged from a locomotor training program at least 6 months prior to enrollment in this study. This group will serve as unexercised control for the "Trained SCI Knee" group or "trained SCI Hip" group | |
| Trained SCI Knee or Trained SCI Hip | Experimental | Individuals with spinal cord injury who have been discharged from a locomotor training program at least 6 months prior to enrollment in this study. Training will specifically focus on rehabilitation of the knee joint or the hip joint. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Trained SCI Knee or Trained SCI Hip | Behavioral | Individuals with SCI will perform downhill walking training 3 times a week for 12 wks with a 4 wk follow-up period. This intervention will be delivered by trained therapists. In order to focus on rehabilitation of knee control or hip control, members of this group will be trained at slow to moderate gait speeds. |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in time to complete 6 minutes of level walking (i.e., the 6 minute walk test) | baseline, 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in time to complete 10 meters of level walking (i.e., the 10 meter walk test) | baseline, 12 weeks | |
| Change from baseline in peak magnitude of sagittal knee power absorption or frontal Hip power during loading response | baseline, 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in maximum voluntary eccentric knee flexion contraction after performing eccentric activity on the contralateral limb (i.e., the contralateral priming effect) | baseline, 12 weeks | |
| Change from baseline in Neuromuscular Recovery Scale score |
Individuals with SCI:
Inclusion Criteria:
Exclusion Criteria:
Note: Use of anti-spasticity and other medications (dose, frequency) will be monitored throughout training and used as a confounding variable in the analyses.
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| Name | Affiliation | Role |
|---|---|---|
| D. Michele M Basso | Ohio State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| D Michele basso | Columbus | Ohio | 43210-2205 | United States |
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| ID | Term |
|---|---|
| D013119 | Spinal Cord Injuries |
| ID | Term |
|---|---|
| D013118 | Spinal Cord Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020196 | Trauma, Nervous System |
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| baseline, 12 weeks |
| Change from baseline in balance function as measured by the Berg Balance Scale score | baseline, 12 weeks |
| Change from Baseline in SCI specific Quality of Life score | baseline, 12 weeks |
| Change from second baseline in time to complete 6 minutes of level walking (i.e., the 6 minute walk test) | 12 weeks, 16 weeks |
| Change from second baseline in time to complete 10 meters of level walking (i.e., the 10 meter walk test) | 12 weeks, 16 weeks |
| Change from second baseline in peak magnitude of sagittal knee power absorption or frontal hip power during loading response | 12 weeks, 16 weeks |
| Change from second baseline in maximum voluntary eccentric knee flexion contraction after performing eccentric activity on the contralateral limb (i.e., the contralateral priming effect) | 12 weeks, 16 weeks |
| Change from second baseline in Neuromuscular Recovery Scale score | 12 weeks, 16 weeks |
| Change from second baseline in balance function as measured by Berg Balance Scale score | 12 weeks, 16 weeks |
| Change from second baseline in SCI specific Quality of Life score | 12 weeks, 16 weeks |
| D014947 | Wounds and Injuries |